Results 61 to 70 of about 257,738 (354)

Heat shock transcription factor-mediated thermal tolerance and cell size plasticity in marine diatoms

Nature Communications
Diatoms are a crucial component of marine ecosystems, recognized for their broad environmental adaptability and wide temperature tolerance. However, the molecular mechanisms underlying their adaptability to diverse temperatures are unknown. In this study,
Dan Huang, Cai-Qin Cheng, Hao-Yun Zhang, Yun Huang, Si-Ying Li, Yi-Tong Huang, Xue-Ling Huang, Lu-Lu Pei, Zhaohe Luo, Li-Gong Zou, Wei-Dong Yang, Xiao-Fei Zheng, Da-Wei Li, Hong-Ye Li   +13 more
doaj   +1 more source

Long-Term, Seasonal and Short-Term Fluctuations in the Water Level of the Southern Baltic Sea

Quaestiones Geographicae, 2014
Aim of this work are analyses of oscillations sea levels in the Southern Baltic on a scale of short-term changes, seasonal and long-term (age). The study was based on observational data in different periods time for tide gauges station of the Polish ...
Wolski Tomasz, Wiśniewski Bernard
doaj   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Rising Tide Center_Webpages_2020

, 2020
Screenshots of the University of Maine\u27s Riding Tide Center ...
University of Maine Rising Tide
core  

PGK1 Suppresses CD8+ T Cell‐Mediated Antitumor Immunity Through CCL2/CCR2/Tumor‐Associated Macrophages Axis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PGK1 in tumor cells upregulates CCL2 expression through activation of the AKT/GSK‐3β/β‐catenin signaling axis, thereby promoting the recruitment and M2 polarization of TAMs and ultimately impairing the infiltration and activation of CD8+ T cells within the HCC tumor microenvironment. ABSTRACT Patients with advanced hepatocellular carcinoma (HCC) have a
Xi Liu, Jianpeng Liu, Zhihao Zhang, Xizhi Yu, Junjie Qian, Limin Ding, Qinchuan Wu, Zhe Yang, Xing‐Yu Luo, Xinjiang Ding, Rong Su, Xiaobo Yu, Yiting Qiao, Shengyong Yin, Haiyang Xie, Lin Zhou, Yuanxing Liu, Shusen Zheng   +17 more
wiley   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Future Change to Tide‐Influenced Deltas

, 2018
Tides tend to widen deltaic channels and shape delta morphology. Here we present a predictive approach to assess a priori the effect of fluvial discharge and tides on deltaic channels.
J. Nienhuis, A. Hoitink, T. Törnqvist
semanticscholar   +1 more source

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Triazine herbicide reduced the toxicity of the harmful dinoflagellate Karenia mikimotoi by impairing its photosynthetic systems

Ecotoxicology and Environmental Safety
Triazine herbicides are common contaminants in coastal waters, and they are recognized as inhibitors of photosystem II, causing significant hinderance to the growth and reproduction of phytoplankton.
Xiang-Wu Chen, Heng Chen, Hai-Ling Zhao, Da-Wei Li, Lin-Jian Ou   +4 more
doaj   +1 more source

Impact of Tropospheric Ozone Modulation Due To El Niño on Tides in the MLT

Geophysical Research Letters, 2023
To assess the impacts of the tropospheric ozone modulation due to El Niño on tides, we performed two simulations by using the Ground‐to‐topside Atmosphere Ionosphere model for Aeronomy model: zonally symmetric ozone density and longitudinal ozone ...
Masaru Kogure, Huixin Liu, Hidekatsu Jin
doaj   +1 more source