Results 51 to 60 of about 72,739 (310)

Tidal currents in the Yucatan Channel [PDF]

Geofísica Internacional, 2007
Currents data from a ten-month period at 197 measuring points covering all Yucatan Channel were processed by harmonic analysis to estimate tidal parameters for the O1, K1, M2 and S2 components.
J. I. González Navarro, J. Sheinbaum, A. Badan, F. Carrillo González, J. Ochoa, J. Candela   +5 more
doaj  

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Chiral‐Encoded Pt‐Ir Surfaces as Apparent Spin Filter for Enhanced Oxygen Reduction

Advanced Science, EarlyView.
The Chiral‐Induced Spin Selectivity (CISS) effect is employed in chiral‐encoded mesoporous Platinum‐Iridium (Pt‐Ir) electrocatalysts to enhance the oxygen reduction reaction (ORR). A break in spin symmetry leads to a substantial antagonistic difference in activity (>200%) when comparing two enantiomorphs of the same electrode.
Zikkawas Pasom, Krissanapat Yomthong, Sopon Butcha, Jonas Fransson, Chularat Wattanakit, Alexander Kuhn   +5 more
wiley   +1 more source

Synchronization‐Dissipation in the Cardiorespiratory System

Advanced Science, EarlyView.
By modeling central nervous coupling and viscoelastic interactions in the cardiorespiratory system we show that synchronization produces a 10% gain in cardiac efficiency in humans. It is surmised that respiratory sinus arrhythmia improves cardiac pumping efficiency by reducing dynamic stress and power dissipation in the pulmonary vasculature.
Joshua R. Border, Alain Nogaret, Andrew Lefevre, Vishal Jain   +3 more
wiley   +1 more source

High Tide or Low Tide

, 2023
People have the remarkable ability to mentally travel back in time and relive events that they experienced in the past. The reliving of memories can include rich details about what happened but also vivid perceptions and affective responses. When memory processes become distorted, they can contribute to the onset and maintenance of mental health ...
openaire   +3 more sources

A Piezo‐Mimetic Ionic Hydrogel Harnessing Joint Motion for Cartilage Repair

Advanced Science, EarlyView.
A piezo‐mimetic ionic hydrogel converts mechanical deformation into bioactive ionic currents via stress‐induced asymmetric ion migration. Coupled with sustained Mg2+ release, this mechano‐electrochemical platform bridges mechanical loading and cellular signaling, enabling load‐adaptive stimulation and enhanced cartilage regeneration. ABSTRACT Articular
Chenyuan Gao, Xinyu Wang, Zhifeng Wu, Xinya Zhang, Xiao Geng, Ti Zhang, Yue Wang, Hongwei Xia, Jun Zhang, Xianbo Qiu, Cuiru Sun, Yingjie Yu, Wenli Dai, Hua Tian, Qing Cai   +14 more
wiley   +1 more source

Geodynamics and Earth Tides Observations from Global to Micro Scale: Introduction

, 2018
The volume collects papers submitted to Pure and Applied Geophysics following a call on the topic “Geodynamics and Earth Tides”. Partly, the authors had participated in the 18th Geodynamics and Earth Tides Symposium held in Trieste, Italy, in June 2016 ...
C. Braitenberg, Hinderer J., Meurers, B., Jahr, T., J. Bogusz, Gross, R., Braitenberg C., Rossi, G., Crossley, D., L. Crescentini, Braitenberg, C., Hinderer, J., Gross R. S., G. Rossi, T. Jahr, R. Gross, B. Meurers, Bogusz J., Crescentini L., D. Crossley, H. Schuh, Meurers B., Schuh, H., Heki K., J. Hinderer, Crossley D., Bogusz, J., Rossi G., Heki, K., K. Heki, Schuch H., Jahr T., Crescentini, L.   +32 more
core   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

PGK1 Suppresses CD8+ T Cell‐Mediated Antitumor Immunity Through CCL2/CCR2/Tumor‐Associated Macrophages Axis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PGK1 in tumor cells upregulates CCL2 expression through activation of the AKT/GSK‐3β/β‐catenin signaling axis, thereby promoting the recruitment and M2 polarization of TAMs and ultimately impairing the infiltration and activation of CD8+ T cells within the HCC tumor microenvironment. ABSTRACT Patients with advanced hepatocellular carcinoma (HCC) have a
Xi Liu, Jianpeng Liu, Zhihao Zhang, Xizhi Yu, Junjie Qian, Limin Ding, Qinchuan Wu, Zhe Yang, Xing‐Yu Luo, Xinjiang Ding, Rong Su, Xiaobo Yu, Yiting Qiao, Shengyong Yin, Haiyang Xie, Lin Zhou, Yuanxing Liu, Shusen Zheng   +17 more
wiley   +1 more source

2018 FDA Tides Harvest [PDF]

, 2019
In 2018, the United States Food and Drug Administration (FDA) approved a total of 59 new drugs, three of them (5%) are TIDES (or also, -tides), two oligonucleotides and one peptide. Herein, the three TIDES approved are analyzed in terms of medical target,
Beatriz G. de la Torre, Albericio, Fernando, Danah Al Shaer, de la Torre, Beatriz G, Othman Al Musaimi, Al Shaer, Danah, Al Musaimi, Othman, Fernando Albericio, Beatriz G. de la Torre   +8 more
core   +1 more source