Results 61 to 70 of about 274,104 (297)

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu   +13 more
wiley   +1 more source

Global structure of thermal tides in the upper cloud layer of Venus revealed by LIR onboard Akatsuki

open access: yes, 2019
Longwave Infrared Camera (LIR) onboard Akatsuki first revealed the global structure of the thermal tides in the upper cloud layer of Venus. The data were acquired over three Venusian years, and the analysis was done over the areas from the equator to the
Akiba, M.   +13 more
core   +1 more source

Corals and Reef‐Dwelling Fish Regulate Carbon Storage and Cycling Processes in Coral Reef Ecosystems

open access: yesAdvanced Science, EarlyView.
Coral reefs are biodiversity hotspots, yet their role in carbon storage and cycling remains poorly understood. Using field surveys and modeling in the South China Sea, we reveal the overlooked potential of carbon storage in reef ecosystems and how reef fish, corals, and surface sediment jointly shape reef carbon reservoirs.
Yiting Chen   +8 more
wiley   +1 more source

High tide or low tide

open access: yes, 2023
People have the remarkable ability to mentally travel back in time and relive events that they experienced in the past. The reliving of memories can include rich details about what happened but also vivid perceptions and affective responses. When memory processes become distorted, they can contribute to the onset and maintenance of mental health ...
openaire   +3 more sources

Outcomes and Duration of Tidal Evolution in a Star-Planet-Moon System

open access: yes, 2012
We formulated tidal decay lifetimes for hypothetical moons orbiting extrasolar planets with both lunar and stellar tides. Previous work neglected the effect of lunar tides on planet rotation, and are therefore applicable only to systems in which the moon'
Barnes   +15 more
core   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

open access: yesAdvanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu   +11 more
wiley   +1 more source

Thermal tides in an assimilation of three years of Thermal Emission Spectromenter data from Mars Global Surveyor [PDF]

open access: yes, 2008
Introduction. Thermal tides are particularly prominent in the Mars atmosphere with the result that temperature and wind fields have a strong dependence on local solar time (LT).
Lewis, S. R.   +2 more
core  

Effects of the Planar Galactic Tides and Stellar Mass on Comet Cloud Dynamics

open access: yes, 2009
We report the first results of a research program to explore the sensitivity of the orbits of Oort cloud comets to changes in the strength of the Galactic tides in the plane of the disk and also to changes in the mass of the host star.
Gonzalez, Guillermo   +2 more
core   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu   +4 more
wiley   +1 more source

Selecting Prices Determinants and Including Spatial Effects in Peer-to-Peer Accommodation

open access: yesISPRS International Journal of Geo-Information, 2020
Peer-to-peer accommodation has grown significantly during the last decades, supported, in part, by digital platforms. These websites make available a wide range of information intended to help the customers’ decision.
Rafael Suárez-Vega, Juan M. Hernández
doaj   +1 more source

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