Results 61 to 70 of about 92,475 (253)

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Analytical model of interaction of tide and river flow [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2006
Hydrodynamic characteristics of a river resulting from interaction of tide and river flow are important since problems regarding flood, salinity intrusion, water quality and sedimentation are ubiquitous.
Phairot Chatanantavet, Suphat Vongvisessomjai   +1 more
doaj  

Impact of Tidal Level Variations on Wave Energy Absorption at Wave Hub

Energies, 2016
The energy absorption of the wave energy converters (WEC) characterized by a limited stroke length —like the point absorbers developed at Uppsala University—depends on the sea level variation at the deployment site. In coastal areas characterized by high
Valeria Castellucci, Mikael Eriksson, Rafael Waters   +2 more
doaj   +1 more source

Titanium-Nitride-Oxide-Coated Versus Everolimus-Eluting Stents in Acute Coronary Syndrome: The Randomized TIDES-ACS Trial.

, 2020
This study sought to compare next-generation cobalt-chromium-based titanium-nitride-oxide (TiNO)-coated stents with a platinum-chromium-based biodegradable polymer everolimus-eluting stent (EES) in patients with acute coronary syndrome (ACS).
Airaksinen, JKE, Frambach, P., Lalmand, J., Tonino, PAL, Kervinen, K., Romppanen, H., Collet, C., Van der Heyden, J., Nammas, W., Penaranda, A.S., De Bruyne, B., Karjalainen, P.P., Sia, J., Pijls, NHJ, Frambach P, De Bruyne B, Romppanen H, Sia J, Nammas W, Penaranda AS, Van der Heyden J, Kervinen K, Lalmand J, Tonino PAL, Pijls NHJ, Airaksinen JKE, Collet C, Karjalainen PP, Juhani K.E. Airaksinen, Hannu Romppanen, Antonio Serra Penaranda, Wail Nammas, Jan Van der Heyden, Carlos Collet, Bernard De Bruyne, Kari Kervinen, Nico H.J. Pijls, Jacques Lalmand, Pasi P. Karjalainen, Peter Frambach, Jussi Sia, Pim A.L. Tonino   +41 more
core   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

The TUBA1B–G3BP2 Axis Sustains p65 Transcriptional Activity to Promote Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
TUBA1B is consistently upregulated in hepatocellular carcinoma and sustains malignant progression by stabilizing G3BP2. By restraining TRIM25‐associated K48‐linked ubiquitination, TUBA1B preserves the G3BP2–IκBα complex and basal NF‐κB/p65 activity. Concurrent TUBA1B/G3BP2 upregulation identifies an aggressive HCC subgroup with enhanced p65 activation ...
Fen Lin, Hechun Lin, Junming Yu, Chao Ge, Lin Mao, Saihua Zhang, Yizi Jin, Yunyu Wu, Taoyang Chen, Jinjun Li, Hong Li   +10 more
wiley   +1 more source

Achieving High‐Instantaneous Pulse Power in Contact‐Separation TENG via Series Capacitive Voltage Control Architecture

Advanced Science, EarlyView.
Conventional contact‐separation triboelectric nanogenerators generate high voltage but deliver limited power due to premature charge dissipation. Here, a capacitive charge reservoir architecture decouples charge accumulation from discharge triggering, enabling sequential voltage amplification via floating‐layer capacitive coupling.
Ajay Haridas CP, Prosenjit Das, Kinsuk Naskar, Titash Mondal   +3 more
wiley   +1 more source

Numerical Modeling of Extreme Sea Levels on the Laptev Sea Coast

Geosciences
The present study is devoted to the analysis of extreme sea level oscillations of the Laptev Sea using the ADCIRC model. The numerical modeling is performed on a high-resolution grid and verified for sea level observations from three tide gauges. We have
Mikhail E. Kulikov, Victor S. Arkhipkin, Igor P. Medvedev, Sergey A. Kovachev, Artem A. Krylov   +4 more
doaj   +1 more source

Selecting Prices Determinants and Including Spatial Effects in Peer-to-Peer Accommodation

ISPRS International Journal of Geo-Information, 2020
Peer-to-peer accommodation has grown significantly during the last decades, supported, in part, by digital platforms. These websites make available a wide range of information intended to help the customers’ decision.
Rafael Suárez-Vega, Juan M. Hernández
doaj   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source