Results 61 to 70 of about 72,739 (310)

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao   +8 more
wiley   +1 more source

Analytical model of interaction of tide and river flow [PDF]

open access: yesSongklanakarin Journal of Science and Technology (SJST), 2006
Hydrodynamic characteristics of a river resulting from interaction of tide and river flow are important since problems regarding flood, salinity intrusion, water quality and sedimentation are ubiquitous.
Phairot Chatanantavet   +1 more
doaj  

Impact of Tidal Level Variations on Wave Energy Absorption at Wave Hub

open access: yesEnergies, 2016
The energy absorption of the wave energy converters (WEC) characterized by a limited stroke length —like the point absorbers developed at Uppsala University—depends on the sea level variation at the deployment site. In coastal areas characterized by high
Valeria Castellucci   +2 more
doaj   +1 more source

Selecting Prices Determinants and Including Spatial Effects in Peer-to-Peer Accommodation

open access: yesISPRS International Journal of Geo-Information, 2020
Peer-to-peer accommodation has grown significantly during the last decades, supported, in part, by digital platforms. These websites make available a wide range of information intended to help the customers’ decision.
Rafael Suárez-Vega, Juan M. Hernández
doaj   +1 more source

Earth tides, earthquake occurrence and earth deformation

open access: yes, 2010
An analysis of Earth deformation, earthquakes and tides has been undertakenusing Earth tide and interferometric SAR data from ESA satellites. The abilityof Earth tides to trigger earthquakes has been investigated by measuring thestatistical relationship ...
Kansowa, Tarek
core  

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang   +8 more
wiley   +1 more source

Microblasting Wound Dressings Mechanically Disrupt Polymicrobial Biofilms to Enhance Healing in Treatment‐Resistant Wounds

open access: yesAdvanced Science, EarlyView.
Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn   +12 more
wiley   +1 more source

Predictive Registry Optimization of Molecular Adsorbates on Solid Surfaces

open access: yesAngewandte Chemie, EarlyView.
Local C–H “spikes” from a π‐conjugated backbone lock into graphene “pockets”. A geometric registry score turns images obtained by scanning tunneling microscopy at the solid/liquid interface into atomic‐scale adsorption models, enabling assignment of surface atropisomers in large π‐conjugated molecules.
David A. Hofmeister   +7 more
wiley   +2 more sources

Synergistic Effect of Gradient Conductivity and Gradient Microstructures Enabled Ultrasensitive and Ultrabroad Linear Flexible Tactile Sensors

open access: yesAdvanced Science, EarlyView.
A design of double gradient effect is proposed to resolve the contradictory optimization on sensitivity and linearity of piezoresistive tactile sensors. The ultrawide linearity is realized by the sequential trigger of pressure‐induced gradient conductivity‐enabled linear current owing to the gradient microstructures.
Yao Fang   +13 more
wiley   +1 more source

A Decoupled Cycling Architecture of Asymmetric Zinc‐Air Battery Unlocks Stable Catalyst Strategy and pH‐Dynamic Influence

open access: yesAngewandte Chemie, EarlyView.
A decoupled cycling architecture along with cost‐effective membrane and efficient catalyst is developed for asymmetric zinc‐air battery. The decoupled design ensures stable operation of catalyst and the pH‐dynamic influence on battery performance is explored, which provides paths for efficient utilization of pH‐decoupling electrolytes.
Yeshu Tan   +6 more
wiley   +2 more sources

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