Results 61 to 70 of about 306,886 (327)

Effects of the Planar Galactic Tides and Stellar Mass on Comet Cloud Dynamics

, 2009
We report the first results of a research program to explore the sensitivity of the orbits of Oort cloud comets to changes in the strength of the Galactic tides in the plane of the disk and also to changes in the mass of the host star.
Gonzalez, Guillermo, Masi, Marco, Secco, Luigi   +2 more
core   +1 more source

RIPK3 Orchestrates Scar‐Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis

Advanced Science, EarlyView.
Beyond signaling cell death, RIPK3 emerges as a critical metabolic regulator in pulmonary fibrosis. This research reveals that RIPK3 promotes PI3K‐AKT signaling in scar‐associated macrophages to fuel polyamine synthesis, independent of its kinase activity.
Tao Yang, Xiao Li, Shuyue Lei, Qingqing Li, Yi Zhang, Zhizhen Hui, Jinjin Ren, Xuelian Yang, Xiaoqian Yang, Chunlan Feng, Yousheng Xu, Dongxin Zhao, Wei Tang   +12 more
wiley   +1 more source

High tide or low tide

, 2023
People have the remarkable ability to mentally travel back in time and relive events that they experienced in the past. The reliving of memories can include rich details about what happened but also vivid perceptions and affective responses. When memory processes become distorted, they can contribute to the onset and maintenance of mental health ...
openaire   +3 more sources

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Tidal Evolution of Close-in Extra-Solar Planets

, 2008
The distribution of eccentricities e of extra-solar planets with semi-major axes a > 0.2 AU is very uniform, and values for e are relatively large, averaging 0.3 and broadly distributed up to near 1.
Brian Jackson, Goldreich P., Gorda S., Hut P., Jeffreys H., Richard Greenberg, Rory Barnes, Verbunt F., Zahn J. P., Zhang K.   +9 more
core   +2 more sources

Reduction of deltaic channel mobility by tidal action under rising relative sea level [PDF]

, 2018
As Holocene river deltas continue to experience sea-level rise, sediment carried by distributary channels counteracts delta-plain drowning. Many deltas worldwide are subject to tidal action, which strongly affects the morphology of distributary channels ...
Finotello, Alvise, Lentsch, Nathan, Paola, Chris   +2 more
core   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

The Tidal Evolution of Local Group Dwarf Spheroidals

, 2007
(Abridged) We use N-body simulations to study the evolution of dwarf spheroidal galaxies (dSphs) driven by galactic tides. We adopt a cosmologically-motivated model where dSphs are approximated by a King model embedded within an NFW halo.
Alan W. McConnachie, Cole S., Efstathiou G., Eke V. R., Ibata R., Irwin M., Jorge Penarrubia, Julio F. Navarro, Kauffmann G., Lahav O., McConnachie A. W., Navarro J. F.   +11 more
core   +1 more source

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4‐VCAM1 Signaling

Advanced Science, EarlyView.
We identified the endothelial RAP2A as a regulator of inflammatory endothelial activation in experimental lung fibrosis and suggest that targeting RAP2A‐mediated signaling may represent a potential strategy to modulate endothelial–immune crosstalk during fibrotic lung injury.
Xiaolan Zheng, Peng Yue, Kaiyu Zhou, Guidong Gong, Yue Zhang, Sha Lin, Xu Liu, Yanjiang Zheng, Siyuan Jing, Junling Guo, Yan Qi, Bi‐Sen Ding, Yimin Hua, Yifei Li   +13 more
wiley   +1 more source

Analytical model of interaction of tide and river flow [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2006
Hydrodynamic characteristics of a river resulting from interaction of tide and river flow are important since problems regarding flood, salinity intrusion, water quality and sedimentation are ubiquitous.
Phairot Chatanantavet, Suphat Vongvisessomjai   +1 more
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