Results 41 to 50 of about 71,932 (261)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Automatic inversion of fracture parameters in tight gas reservoirs based on gas production profile [PDF]

Youqicang pingjia yu kaifa
Accurately determining hydraulic fracture parameters is crucial for guiding the design of fracturing treatments and predicting single-well production.
XIAO Honglin, BU Chunliang, HOU Fu, TANG Huiying, WANG Yiyun, LUO Shangui
doaj   +1 more source

Geochemical Characteristics and Origin of Tight Gas in Member Two of the Upper Triassic Xujiahe Formation in Western Sichuan Depression, Sichuan Basin, SW China

Frontiers in Earth Science, 2022
Natural gas in the tight sandstone reservoirs in Member two of the Upper Triassic Xujiahe Formation in the Western Sichuan Depression of the Sichuan Basin has complex geochemical characteristics, and the origin and source of the tight gas are revealed ...
Xiaoqi Wu, Xiaoqi Wu, Quanyou Liu, Quanyou Liu, Yingbin Chen, Yingbin Chen, Jun Yang, Jun Yang, Huasheng Zeng, Huasheng Zeng, Huaji Li   +10 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Pore characteristics of clay minerals in the Qingshankou shale,Songliao Basin, China: unravelling the effects of illitization

Frontiers in Earth Science
IntroductionClay minerals are critical components of lacustrine shale systems, where their associated pores govern reservoir properties. The diagenetic transformation of these minerals, particularly illitization, profoundly impacts reservoir quality, yet
Xiaohua Jiang, Xiaohua Jiang, Xiaohua Jiang, Rukai Zhu, Rukai Zhu, Rukai Zhu, Songtao Wu, Songtao Wu, Songtao Wu, Jingya Zhang, Jingya Zhang, Jingya Zhang, Zhichao Yu, Zhichao Yu, Modi Guan, Modi Guan, Lihua Ding, Lihua Ding   +17 more
doaj   +1 more source

Formation condition of deep gas reservoirs in tight sandstones in Kuqa Foreland Basin

Petroleum Research, 2018
Due to the high expense of deep oil and gas exploration, prediction of gas-bearing properties before drilling is crucial for deep gas reservoir of tight sandstone. Deep tight sandstone gas fields in Kuqa Foreland Basin are characterized by high abundance,
Xuesong Lu, Mengjun Zhao, Keyu Liu, Qingong Zhuo, Junjia Fan, Zhichao Yu, Yanjie Gong   +6 more
doaj   +1 more source

Unconventional natural gas accumulation system

Natural Gas Industry B, 2022
Unlike conventional natural gas accumulations, unconventional ones have obvious particularity in reservoir forming conditions, enrichment mechanism, distribution modes, prediction method, and exploration technology.
Zhijun Jin, Jinchuan Zhang, Xuan Tang
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source