Results 41 to 50 of about 72,391 (263)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Automatic inversion of fracture parameters in tight gas reservoirs based on gas production profile [PDF]
Youqicang pingjia yu kaifaAccurately determining hydraulic fracture parameters is crucial for guiding the design of fracturing treatments and predicting single-well production.
XIAO Honglin, BU Chunliang, HOU Fu, TANG Huiying, WANG Yiyun, LUO Shangui
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Frontiers in Earth Science, 2022 Natural gas in the tight sandstone reservoirs in Member two of the Upper Triassic Xujiahe Formation in the Western Sichuan Depression of the Sichuan Basin has complex geochemical characteristics, and the origin and source of the tight gas are revealed ...
Xiaoqi Wu +10 more
doaj +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Frontiers in Earth ScienceIntroductionClay minerals are critical components of lacustrine shale systems, where their associated pores govern reservoir properties. The diagenetic transformation of these minerals, particularly illitization, profoundly impacts reservoir quality, yet
Xiaohua Jiang +17 more
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Formation condition of deep gas reservoirs in tight sandstones in Kuqa Foreland Basin
Petroleum Research, 2018 Due to the high expense of deep oil and gas exploration, prediction of gas-bearing properties before drilling is crucial for deep gas reservoir of tight sandstone. Deep tight sandstone gas fields in Kuqa Foreland Basin are characterized by high abundance,
Xuesong Lu +6 more
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Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Unconventional natural gas accumulation system
Natural Gas Industry B, 2022 Unlike conventional natural gas accumulations, unconventional ones have obvious particularity in reservoir forming conditions, enrichment mechanism, distribution modes, prediction method, and exploration technology.
Zhijun Jin, Jinchuan Zhang, Xuan Tang
doaj +1 more source