Results 61 to 70 of about 87,683 (308)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Across-Time Change and Variation in Cultural Tightness-Looseness. [PDF]
, 2015 Cultural tightness-looseness, a dimension which describes the strength, multitude, and clarity of social norms in a culture, has proved significant in explaining differences between cultures.
Anu Realo +7 more
core +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Embeddings into pseudocompact spaces of countable tightness
, 2004 A method for embedding certain countable spaces into a pseudocompact Tychonoff space of countable tightness is given. In particular, this permits construction under [CH] of two pseudocompact Tychonoff spaces of countable tightness, one does not have ...
PAVLOV O. I., BELLA, Angelo
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The Correlation between Sacroiliac Joint Dysfunction and Hip Adductor Tightness [PDF]
Annals of Applied Sport Science, 2022 Background. Low back pain is one of the ten most common causes of disability, and sacroiliac joint dysfunction is one of the most common causes of it. Objectives.
Mohammad Hassabi +5 more
doaj
Application of some graph invariants to the analysis of multiprocessor interconnection networks [PDF]
Yugoslav Journal of Operations Research, 2008 Let G be a graph with diameter D, maximum vertex degree Δ, the largest eigenvalue λ1 and m distinct eigenvalues. The products mΔ and (D+1) λ1 are called the tightness of G of the first and second type, respectively.
Cvetković Dragoš, Davidović Tatjana
doaj +1 more source
Tightness to control_Lab 10012020
, 2020 We predict that participants assigned to the high (vs.
AY M
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source