Results 21 to 30 of about 500,835 (209)

Combined IL-2, agonistic CD3 and 4-1BB stimulation preserve clonotype hierarchy in propagated non-small cell lung cancer tumor-infiltrating lymphocytes

Journal for ImmunoTherapy of Cancer, 2022
Background Adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TIL) yielded clinical benefit in patients with checkpoint blockade immunotherapy-refractory non-small cell lung cancer (NSCLC) prompting a renewed interest in TIL-ACT.
Anirban Maitra, Alexandre Reuben, Chantale Bernatchez, Marie-Andree Forget, Donastas Sakellariou-Thompson, Tina Cascone, Annikka Weissferdt, Jianjun Zhang, Boris Sepesi, Ignacio Wistuba, Ara A Vaporciyan, Marcelo V Negrao, Lorenzo Federico, John V Heymach, Don L Gibbons, Cara L Haymaker, Junya Fujimoto, Jack A Roth, Parin Shah, Peixin Jiang, Roohussaba Khairullah, Yan Long, Shiaw-Yih Lin, Meredith L Frank, Chantal Alexia Neutzler, Chi-Wan B Chow, Kyle Gregory Mitchell, Daniel J McGrail   +27 more
doaj   +1 more source

Why do tumor-infiltrating lymphocytes have variable efficacy in the treatment of solid tumors?

Frontiers in Immunology, 2022
Lymphocytes in tumor tissue are called tumor-infiltrating lymphocytes (TILs), and they play a key role in the control and treatment of tumor diseases.
Biaoru Li
doaj   +1 more source

Covid-19. Dør-til-dør-aksjoner, mobile teststasjoner og endring i testandel blant norsk- og utenlandsfødte i bydel Stovner, Oslo [PDF]

, 2021
Høy testandel er viktig i arbeidet mot spredning av covid-19. Stovner bydel gjennomførte dør-til-dør-aksjoner der innbyggerne ble oppfordret til å teste seg, i februar-mars 2021. I tilknytning til aksjonene ble det utplassert mobile testanlegg.
Vinjerui, Kristin Hestmann, Fretheim, Atle, Elgersma, Ingeborg Hess   +2 more
core   +7 more sources

Prognostic Landscape of Tumor-Infiltrating T and B Cells in Human Cancer

Frontiers in Immunology, 2022
Recently, immunotherapy targeting tumor-infiltrating lymphocytes (TILs) has emerged as a critical and promising treatment in several types of cancer. However, not all cancer types have been tested in immunotherapeutic trials, and different patients and ...
Ming Zheng, Ming Zheng, Yi-Ming Li, Yi-Ming Li, Zhen-Yu Liu, Zhen-Yu Liu, Xin Zhang, Yinghui Zhou, Yinghui Zhou, Yinghui Zhou, Jian-Li Jiang, Jian-Li Jiang, Ping Zhu, Ping Zhu, Xiang-Min Yang, Xiang-Min Yang, Juan Tang, Juan Tang, Zhi-Nan Chen, Zhi-Nan Chen   +19 more
doaj   +1 more source

The association between CD3+ and CD8+tumor-infiltrating lymphocytes (TILs) and prognosis in patients with pancreatic adenocarcinoma

Cancer Treatment and Research Communications, 2023
Background: : Pancreatic adenocarcinoma (PDAC), with more than 250,000 deaths each year, is the eighth leading cause of death worldwide, with a five-year survival of less than 5% and a median recurrence time between 5 and 23 months.
Mahshid Panahi, Fereshteh Rezagholizadeh, Shabnam Mollazadehghomi, Pooya Farhangnia, Mohammad Hadi Karbalaie Niya, Hossein Ajdarkosh, Fahimeh Safarnezhad Tameshkel, Seyed Mohammad Heshmati   +7 more
doaj   +1 more source

Immune microenvironment profiling of gastrointestinal stromal tumors (GIST) shows gene expression patterns associated to immune checkpoint inhibitors response

OncoImmunology, 2019
Few studies were conducted investigating the immunological profiles in gastrointestinal stromal tumors (GIST). Adaptive and innate immune cells are present in the tumor microenvironment, indicating GIST as inflamed tumors.
Maria A. Pantaleo, Giuseppe Tarantino, Claudio Agostinelli, Milena Urbini, Margherita Nannini, Maristella Saponara, Chiara Castelli, Silvia Stacchiotti, Elena Fumagalli, Lidia Gatto, Donatella Santini, Antonio De Leo, Teresa Marafioti, Ayse Akarca, Elena Sabattini, Andrea Pession, Andrea Ardizzoni, Valentina Indio, Annalisa Astolfi   +18 more
doaj   +1 more source

Randomized phase II trial of lymphodepletion plus adoptive cell transfer of tumor-infiltrating lymphocytes, with or without dendritic cell vaccination, in patients with metastatic melanoma

Journal for ImmunoTherapy of Cancer, 2021
Background The adoptive transfer of tumor-infiltrating lymphocytes (TIL) has demonstrated robust efficacy in metastatic melanoma patients. Tumor antigen–loaded dendritic cells (DCs) are believed to optimally activate antigen-specific T lymphocytes.
Sapna Patel, Adi Diab, Michael A. Davies, Jennifer L. McQuade, Michael K. Wong, Isabella C. Glitza, Hussein A. Tawbi, Rodabe N. Amaria, Chantal Saberian, Enrique Alvarez, Amer M. Najjar, Laszlo G. Radvanyi, Cara L. Haymaker, Roland L. Bassett, Silvana C. Faria, Sapna Parshottam, Victor Prieto, Elizabeth J. Shpall   +17 more
doaj   +1 more source

Tumor Hypoxia and CD8+ T‐Cell Infiltration in Patients With Advanced Laryngeal Cancer

Otolaryngology–Head and Neck Surgery, Volume 173, Issue 3, Page 645-650, September 2025.
Abstract Objective We assessed correlations between tumor carbonic anhydrase IX (CAIX) staining, as a marker of tumor hypoxia, and CD8+ T‐cell infiltration in a cohort of patients with advanced laryngeal squamous cell carcinoma undergoing a bioselection approach for definitive treatment. Study Design Retrospective cohort study.
Joshua D. Smith, Elizabeth Gensterblum‐Miller, David W.A. Forner, Pratyusha Yalamanchi, Marisa R. Buchakjian, Steven B. Chinn, Andrew G. Shuman, Keith A. Casper, Kelly M. Malloy, Chaz L. Stucken, Scott A. Mclean, Michelle L. Mierzwa, Jennifer Shah, Paul L. Swiecicki, Francis P. Worden, Mark E.P. Prince, Matthew E. Spector, J. Chad Brenner, Molly E. Heft Neal   +18 more
wiley   +1 more source

Baltikums befrielse

Nordisk Østforum
Bogen Baltikums befrielse  fra 2023 af T. Berglund og N. Sennerteg giver en meget bred fremstilling med mange personlige beretninger af krigene i Baltikum i 1918–1920, der førte til at estere, letter og litauere kunne oprette egne stater.
Mads Michael Hastrup Nilsson
doaj   +1 more source

Unlocking the Genetic Diversity within A Middle-East Panel of Durum Wheat Landraces for Adaptation to Semi-arid Climate

Agronomy, 2018
Drought is the major environmental factor limiting wheat production worldwide. Developing novel cultivars with greater drought tolerance is the most viable solution to ensure sustainable agricultural production and alleviating threats to food-security ...
Salam Y. Abu-Zaitoun, Kottakota Chandrasekhar, Siwar Assili, Munqez J. Shtaya, Rana M. Jamous, Omar B. Mallah, Kamal Nashef, Hanan Sela, Assaf Distelfeld, Nawal Alhajaj, Mohammed S. Ali-Shtayeh, Zvi Peleg, Roi Ben-David   +12 more
doaj   +1 more source