Results 91 to 100 of about 331,160 (298)

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

Advanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso, Sara Carpi, Laura Colagiorgio, Miriam De Sarlo, Mariacristina Gagliardi, Marco Cecchini   +5 more
wiley   +1 more source

Reduced systemic vascular resistance in healthy volunteers with presyncopal symptoms during a nitrate-stimulated tilt-table test.

British Journal of Clinical Pharmacology, 2011
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Nitrates may facilitate syncope through various pathways, but the precise mechanism of nitrate-induced syncope is still under debate.
A. Tahvanainen, Jenni K Koskela, Miia H. Leskinen, E. Ilveskoski, K. Nordhausen, M. Kähönen, T. Kööbi, J. Mustonen, I. Pörsti   +8 more
semanticscholar   +1 more source

A Case‐Based Reasoning Approach to Model Manufacturing Constraints for Impact Extrusion

Advanced Engineering Materials, EarlyView.
A hybrid modeling approach is presented that combines constraint‐based process modeling and case‐based reasoning. The model formalizes manufacturing constraints and integrates simulation data to model complex manufacturing processes. The approach supports manufacturability analysis during product design through an adaptive modeling environment.
Kevin Herrmann, Eduard Ortlieb, Hendrik Wester, Paul Christoph Gembarski, Bernd‐Arno Behrens, Roland Lachmayer   +5 more
wiley   +1 more source

Assessing the Ecological Value: Monetizing Process Innovations in Tailored Forming

Advanced Engineering Materials, EarlyView.
This article introduces a method for evaluating the sustainability of innovations, even with limited data. The method is illustrated through an analysis of the “Tailored Forming” technology, which explores the impact of sustainability on economic value added.
Jonas Schneider, Jan Westing, Matthias Schmidt, Peter Nyhuis, Vivian Katharina Kuprat   +4 more
wiley   +1 more source

Tilt teste no diagnóstico diferencial da "epilepsia" resistente ao tratamento Tilt table test in the differential diagnosis of refractory "epilepsy"

Arquivos Brasileiros de Cardiologia, 2006
A epilepsia é uma das causas mais freqüentes de distúrbios neurológicos em adultos jovens. Relatamos um caso em que uma paciente conviveu durante doze anos com o diagnóstico de epilepsia resistente ao tratamento, quando, na verdade, a causa de seus ...
Renata Rodrigues Teixeira de Castro, Antonio Claudio Lucas da Nóbrega   +1 more
doaj   +1 more source

Simulation of Inhomogeneous Refractive Index Fields Induced by Hot Tailored Forming Components

Advanced Engineering Materials, EarlyView.
This article presents a simulation model for simulating inhomogeneous refractive index fields (IRIF) in hot‐forged components, accounting for thermal influences and complex geometries. Through this simulation, a priori knowledge about the propagation of the IRIF can be obtained, allowing for the positioning of the component or an optical measurement ...
Pascal Kern, Lennart Hinz, Markus Kästner, Eduard Reithmeier   +3 more
wiley   +1 more source

Optimization of suspension system and sensitivity analysis for improvement of stability in a midsize heavy vehicle

Engineering Science and Technology, an International Journal, 2017
This paper presents a method for systematic investigations on static and dynamic roll behavior and improvement to the stability dynamics based on increasing roll stiffness of the suspension.
Emre Sert, Pınar Boyraz
doaj   +1 more source

Non‐Destructive and Mechanical Characterization of the Bond Quality of Co‐Extruded Titanium‐Aluminum Profiles

Advanced Engineering Materials, EarlyView.
This study investigates the bond quality of co‐extruded aluminum–titanium hybrid profiles, focusing on the lateral angular co‐extrusion (LACE) process. It examines how heat treatments (HT) affect intermetallic phase formation, bond strength, and material properties.
Norman Mohnfeld, Ahmed Dewidar, Karim Qarbi, Hendrik Wester, Florian Patrick Schäfke, Alexej Verschinin, Hans Jürgen Maier, Sebastian Barton, Christian Klose, Johanna Uhe   +9 more
wiley   +1 more source

A Different Perspective on the Solid Lubrication Performance of Black Phosphorous: Friend or Foe?

Advanced Engineering Materials, EarlyView.
Researchers investigate black phosphorous (BP) as a standalone solid lubricant coating through ball‐on‐disc linear‐reciprocating sliding experiments in dry conditions. Testing on different metals shows BP doesn't universally reduce friction and wear. However, it achieves 33% friction reduction on rougher iron surfaces and 23% wear reduction on aluminum.
Matteo Vezzelli, Manel Rodríguez Ripoll, Sabine Schwarz, Ali Erdemir, Maria Clelia Righi, Carsten Gachot   +5 more
wiley   +1 more source

Bistable Mechanisms 3D Printing for Mechanically Programmable Vibration Control

Advanced Engineering Materials, EarlyView.
This work introduces a 3D‐printed bistable mechanism integrated into tuned mass dampers (TMDs) for mechanically adaptive passive vibration suppression. Through optimized geometry, the bistable design provides adaptable vibration reduction across a broad range of scenarios, achieving effective vibration mitigation without complex controls or external ...
Ali Zolfagharian, Frédéric Demoly, Mohammad Lakhi, Bernard Rolfe, Mahdi Bodaghi   +4 more
wiley   +1 more source