Results 61 to 70 of about 54,390 (293)

Evaluation of a single-stage isoproterenol-tilt table test in patients with syncope

, 1993
Objectives. The purpose of this study was to compare clinical outcomes and tilt test variables between a single-stage tilt test with an infusion of 5 μg/min of isoproterenol and a conventional multistage test with infusions of 0, 2 and 5 μg/min of ...
Sheldon, Robert
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Study on Centroid Height Prediction of Non-Rigid Vehicle Based on Deep Learning Combined Model

Sensors
The height of the center of gravity (ZCG) is a critical parameter for evaluating vehicle safety and performance. Systematic errors arise in ZCG measurement via the tilt-table test method due to unlocked suspension systems and variable sprung mass ...
Guoqiang Pang, Zhiquan Xiao, Zhanwen Cai, Pei Wang   +3 more
doaj   +1 more source

The role of tilt table test in diagnostics of syncope [PDF]

, 2017
Sinkopa je stanje koje se dogodi velikom dijelu populacije barem jednom u životu. Dolazi do prolaznog gubitka svijesti zbog prolazne globalne hipoperfuzije mozga. U ovom radu na Klinici za bolesti srca i krvnih žila KBC Zagreb obrađeni su rezultati “tilt-
Crevar, Arijana
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Relationship between the mean platelet volume values and tilt-table test results in patients with vasovagal syncope

Medicine Science, 2018
Impaired sympathovagal balance, the main pathophysiological mechanism under the vasovagal syncope (VVS), may play a role on platelet sizes. Although it has been shown that mean platelet volume (MPV) is increased in patients with vasovagal syncope, its ...
Yalcin Gokoglan, Erkan Yildirim
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Tilt table testing in neurology and clinical neurophysiology

Clinical Neurophysiology, 2016
Reflex syncope is responsible for 1-6% of hospital admissions and the economic burden of syncope is huge. A considerable part of these high costs is still spent on tests that are not indicated. Till now few neurologists have taken an interest in syncope and tilt table testing (TTT).
Saal, D.P., Thijs, R.D., Dijk, J.G. van
openaire   +4 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source