Results 51 to 60 of about 13,767,586 (365)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Tilt training as a treatment for reflex syncope: a multimodal approach!?

Frontiers in Neuroscience
PurposeReflex syncope is a burdensome disease with considerable repercussions on the quality of life. Tilt training is a therapeutic option, but evidence on this topic is scarce and outdated. Hyperventilation is oftentimes associated with reflex syncope.
Miek Hornikx, Peter Haemers, Peter Haemers, Linda Stans, Tomas Robyns, Tomas Robyns, Christophe Garweg, Christophe Garweg, Joris Ector, Joris Ector, Bert Vandenberk, Bert Vandenberk, Rik Willems, Rik Willems   +13 more
doaj   +1 more source

Signal-to-Noise Eigenmode Analysis of the Two-Year COBE Maps

, 1994
To test a theory of cosmic microwave background fluctuations, it is natural to expand an anisotropy map in an uncorrelated basis of linear combinations of pixel amplitudes --- statistically-independent for both the noise and the signal.
C. Bennett, E. F. Bunn, E. L. Wright, E. L. Wright, G. F. Smoot, J. R. Bond, J. R. Bond, J. R. Bond, J. R. Bond, J. R. Bond, J. Richard Bond, K. Ganga, K. Ganga, K. Gorski   +13 more
core   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Temporal artery flow response during the last minute of a head up tilt test, in relation with orthostatic intolerance after a 60 day head-down bedrest. [PDF]

PLoS ONE, 2011
OBJECTIVE: Check if the Temporal flow response to Tilt could provide early hemodynamic pattern in the minutes preceding a syncope during the Tilt test performed after a 60-d head down bedrest (HDBR). METHOD: Twenty-one men divided into 3 groups [Control (
Philippe Arbeille, Ming Yuan, Yanqiang Bai, Shizhong Jiang, Gullemette Gauquelin, Patrick Aubry, Yuming Wan, Marc Antoine Custaud, Yinghui Li   +8 more
doaj   +1 more source

Functional role and folding properties of the glucan‐binding domain of oral bacterial glucansucrase

FEBS Letters, EarlyView.
The role of the glucan‐binding domain in Streptococcus sobrinus glucansucrase was examined, focusing on its impact on enzymatic activity, dextran binding, and structural stability of deletion mutants and a circularly permuted protein. Our research revealed that glucosyl transfer efficiency is linked to cooperative interdomain folding.
Hideyuki Komatsu, Takayuki Sadakane, Yudai Murata, Junichi Taira, Hiroshi Sakamoto, Takao Kodama   +5 more
wiley   +1 more source

Surface flux transport simulations: Effect of inflows toward active regions and random velocities on the evolution of the Sun's large-scale magnetic field

, 2015
Aims: We aim to determine the effect of converging flows on the evolution of a bipolar magnetic region (BMR), and to investigate the role of these inflows in the generation of poloidal flux.
Cameron, Robert H., Martin-Belda, David
core   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Gender-related specificities of photoplethysmogram spectral assessment dynamics in healthy subjects during the passive tilt test

Russian Open Medical Journal, 2021
The goal of our study was to investigate gender-related specificities of photoplethysmogram (PPG) spectral assessment dynamics in healthy individuals during the passive tilt test.
Margarita А. Simonyan, Ekaterina I. Borovkova, Yurii М. Ishbulatov, Viktoriia V. Skazkina, Anatoly S. Karavaev, Vladimir A. Shvartz, Anton R. Kiselev   +6 more
doaj   +1 more source

Measurement and Compensation of Horizontal Crabbing at the Cornell Electron Storage Ring Test Accelerator

, 2014
In storage rings, horizontal dispersion in the rf cavities introduces horizontal-longitudinal (xz) coupling, contributing to beam tilt in the xz plane. This coupling can be characterized by a "crabbing" dispersion term {\zeta}a that appears in the normal
Chatterjee, A., Ehrlichman, M. P., Hartung, W., Heltsley, B., Peterson, D. P., Rider, N., Rubin, D., Sagan, D., Shanks, J. P., Wang, S. T.   +9 more
core   +2 more sources