Results 51 to 60 of about 14,186,708 (331)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The role and importance of the tilt table test in pediatrics: Single-center experience and review of literature

Heart and Mind, 2020
Introduction: The head-up tilt table test is noninvasive diagnostic procedure, which is used in the diagnosis of syncope. Syncope presents a benign short-term disorder of cerebral circulation with the sudden loss of consciousness and muscle tone.
Zijo Begic, Nedim Begic, Edin Begic, Naida Spahovic   +3 more
doaj   +1 more source

Effects of head tilt on visual field testing with a head-mounted perimeter imo. [PDF]

PLoS ONE, 2017
A newly developed head-mounted perimeter termed "imo" enables visual field (VF) testing without a fixed head position. Because the positional relationship between the subject's head and the imo is fixed, the effects of head position changes on the test ...
Sayaka Yamao, Chota Matsumoto, Hiroki Nomoto, Takuya Numata, Mariko Eura, Marika Yamashita, Shigeki Hashimoto, Sachiko Okuyama, Shinji Kimura, Kenzo Yamanaka, Yasutaka Chiba, Makoto Aihara, Yoshikazu Shimomura   +12 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Tilt-Strain Changes Linked to a Jacking System Test

Civil and Environmental Engineering, 2022
A sector of the San Marco Hospital (Catania, Italy) was the subject of a jacking test in order to demonstrate the substitutability of the seismic isolator. A monitoring system, included tiltmeters and strain gauges, was applied to one column.
Gambino Salvatore, Falzone Giuseppe, Ferro Angelo, Laudani Giuseppe, Scuderi Luciano   +4 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Reducing tilt-to-length coupling for the LISA test mass interferometer [PDF]

, 2017
Objects sensed by laser interferometers are usually not stable in position or orientation. This angular instability can lead to a coupling of angular tilt to apparent longitudinal displacement—tilt-to-length coupling (TTL).
M. Tröbs, S. Schuster, M. Lieser, M. Zwetz, M. Chwalla, K. Danzmann, G. F. Barranco, E. Fitzsimons, O. Gerberding, G. Heinzel, C. Killow, M. Perreur-Lloyd, D. Robertson, T. S. Schwarze, G. Wanner, H. Ward   +15 more
semanticscholar   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Carotid sinus hypersensitivity as a cause of multiple falls in an elderly patient: a case report

Revista Médica de Minas Gerais
The carotid sinus is a neurovascular structure composed of baroreceptors responsible for detecting changes in blood pressure. When the baroreflex response of the carotid sinus becomes excessively sensitive, it can result in symptoms such as syncope ...
Thaís Franco Simas, Alice Scaglione dos Santos, Maria Fernanda Leonardi, Pietra Lopes Monti, Luana Takei, Izabella Araújo Machado, Paula Rezende Rodrigues, Maria Carolyna Fonseca Batista Arbex   +7 more
doaj   +1 more source