Results 51 to 60 of about 329,670 (339)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source

Carotid sinus hypersensitivity as a cause of multiple falls in an elderly patient: a case report

Revista Médica de Minas Gerais
The carotid sinus is a neurovascular structure composed of baroreceptors responsible for detecting changes in blood pressure. When the baroreflex response of the carotid sinus becomes excessively sensitive, it can result in symptoms such as syncope ...
Thaís Franco Simas, Alice Scaglione dos Santos, Maria Fernanda Leonardi, Pietra Lopes Monti, Luana Takei, Izabella Araújo Machado, Paula Rezende Rodrigues, Maria Carolyna Fonseca Batista Arbex   +7 more
doaj   +1 more source

Temporal artery flow response during the last minute of a head up tilt test, in relation with orthostatic intolerance after a 60 day head-down bedrest. [PDF]

PLoS ONE, 2011
OBJECTIVE: Check if the Temporal flow response to Tilt could provide early hemodynamic pattern in the minutes preceding a syncope during the Tilt test performed after a 60-d head down bedrest (HDBR). METHOD: Twenty-one men divided into 3 groups [Control (
Philippe Arbeille, Ming Yuan, Yanqiang Bai, Shizhong Jiang, Gullemette Gauquelin, Patrick Aubry, Yuming Wan, Marc Antoine Custaud, Yinghui Li   +8 more
doaj   +1 more source

Measurement and Compensation of Horizontal Crabbing at the Cornell Electron Storage Ring Test Accelerator

, 2014
In storage rings, horizontal dispersion in the rf cavities introduces horizontal-longitudinal (xz) coupling, contributing to beam tilt in the xz plane. This coupling can be characterized by a "crabbing" dispersion term {\zeta}a that appears in the normal
Chatterjee, A., Ehrlichman, M. P., Hartung, W., Heltsley, B., Peterson, D. P., Rider, N., Rubin, D., Sagan, D., Shanks, J. P., Wang, S. T.   +9 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Subband Engineering Even-Denominator Quantum Hall States

, 2010
Proposed even-denominator fractional quantum Hall effect (FQHE) states suggest the possibility of excitations with non-Abelian braid statistics. Recent experiments on wide square quantum wells observe even-denominator FQHE even under electrostatic tilt ...
B. I. Halperin, C. May, J. K. Jain, M. R. Peterson, M. Troyer, V. W. Scarola   +5 more
core   +1 more source

Variation in pelvic morphology may prevent the identification of anterior pelvic tilt [PDF]

, 2008
Pelvic tilt is often quantified using the angle between the horizontal and a line connecting the anterior superior iliac spine (ASIS) and the posterior superior iliac spine (PSIS).
Bowker, P, Graham-Smith, P, Herrington, LC, Nester, CJ, Preece, SJ, Willan, P   +5 more
core   +3 more sources

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Hemodynamic Response to the Head-Up Tilt Test in Patients With Syncope as a Predictor of the Test Outcome: A Meta-Analysis Approach

Frontiers in Physiology, 2019
Aim: The paper presents a meta-analysis of studies comparing hemodynamic parameters: heart rate (HR), systolic blood pressure (sBP), diastolic blood pressure (dBP), and stroke volume (SV) measured during head-up tilt table test (HUTT) in patients with ...
Katarzyna Buszko, Sławomir Kujawski, Julia L. Newton, Paweł Zalewski   +3 more
doaj   +1 more source