Results 171 to 180 of about 18,801,342 (289)

TIM-3 in AML: a janus-faced orchestrator of immune exhaustion and leukemic self-renewal. [PDF]

Cancer Cell Int
Hjazi A.
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

TIM-3+ Macrophages: Insights into Their Role in Cancer and Inflammation. [PDF]

Int J Mol Sci
Maksimova A, Tyrinova T, Chernykh E.
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Immunopathogenesis of severe pneumonia in children with emphasis on CD4+ T cells, Tim-3 and cytokine-mediated immune dysregulation. [PDF]

Front Med (Lausanne)
Cao F, Zhang Q, Yan L.
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Correction: Bibliometric analysis of knowledge maps and future trends of TIM-3 in cancer. [PDF]

Front Oncol
Lv S, Huang S, Li L, Lin K, Zhang H, Huang Y.   +5 more
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Bibliometric analysis of knowledge maps and future trends of TIM-3 in cancer. [PDF]

Front Oncol
Lv S, Huang S, Li L, Lin K, Zhang H, Huang Y.   +5 more
europepmc   +1 more source

Differential expression and biochemical activity of the immune receptor Tim-3 in healthy and malignant human myeloid cells [PDF]

, 2015
Bernhard F. Gibbs, Bardelli, Marco, Sumbayev, Vadim V., Gibbs, Bernhard F, Varani, Luca, Vadim V. Sumbayev, Goncalves Silva, Isabel, Marco Bardelli, Luca Varani, Isabel Gonçalves Silva   +9 more
core   +1 more source