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Asia-Pacific Journal of Clinical Oncology, 2020
AbstractAimTo characterize the distribution of T cell immunoglobulin mucin‐domain‐containing‐3 (Tim‐3) within the exhausted T cells in patients with newly diagnosed acute myeloid leukemia (AML) and AML in complete remission.MethodsTim‐3 expression and coexpression with PD‐1, CD244, and CD57 in CD3+, CD4+, and CD8+T cells were analyzed by multicolored ...
Jiaxiong Tan +7 more
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AbstractAimTo characterize the distribution of T cell immunoglobulin mucin‐domain‐containing‐3 (Tim‐3) within the exhausted T cells in patients with newly diagnosed acute myeloid leukemia (AML) and AML in complete remission.MethodsTim‐3 expression and coexpression with PD‐1, CD244, and CD57 in CD3+, CD4+, and CD8+T cells were analyzed by multicolored ...
Jiaxiong Tan +7 more
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Current Opinion in Immunology, 2006
T cell immunoglobulin and mucin domain (TIM)-3 is a molecule expressed on terminally differentiated murine Th1 cells but not on Th2 cells. Identification of galectin-9 as a ligand for TIM-3 has now firmly established the TIM-3-galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. TIM-3 is similarly expressed on human Th1
Ana C, Anderson, David E, Anderson
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T cell immunoglobulin and mucin domain (TIM)-3 is a molecule expressed on terminally differentiated murine Th1 cells but not on Th2 cells. Identification of galectin-9 as a ligand for TIM-3 has now firmly established the TIM-3-galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. TIM-3 is similarly expressed on human Th1
Ana C, Anderson, David E, Anderson
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Role of TIM-3 in ovarian cancer
Clinical and Translational Oncology, 2017Evidences have suggested that immunotherapy for ovarian cancer is effective. Immune checkpoints have emerged in the field of cancer immunotherapy. Multiple studies have shown negative regulation of TIM-3 expression on CD4+ and CD8+ T cells and other immunocytes.
Y, Xu +4 more
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Importance of photophosphatidylserine and Tim-3 in photoimmunotherapy
RSC Medicinal Chemistry, 2022Natural killer (NK) cells help regulate autoimmune reactions, but overactivation causes harm.
Akshansh Sharma +3 more
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Tim-3 expression in human kidney allografts
Transplant Immunology, 2007Tim-3 was recently described as a Th1-specific molecule, participating in the regulation of immune responses and in the induction of allograft tolerance. Here, we studied Tim-3 mRNA expression together with molecular markers of T-cell activation and cytotoxicity, in rejected human kidney grafts.Twenty human kidney grafts that had undergone nephrectomy ...
Ponciano, Viviane C. +7 more
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Identification of Different Form Tim-3 Proteins by a Unique Set of Tim-3 Monoclonal Antibodies
Journal of Immunotherapy, 2019T-cell immunoglobulin and mucin domain-3 (Tim-3) has been suggested to be a critical immune checkpoint target for cancer immunotherapy. However, limited progress with Tim-3 immunotherapy has been achieved over the last decade due to the lack of specific Tim-3 monoclonal antibodies.
Zhuocai, Wang +7 more
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TIM‐3 Expression in Endometriosis
American Journal of Reproductive ImmunologyABSTRACTProblemEndometriosis is a prevalent chronic gynecological disease linked to immune dysfunction. The protein T‐cell immunoglobulin and mucin domain‐containing protein 3 (TIM‐3) plays a crucial role in immune system balance. Malfunction of TIM‐3 may result in excessive immune activation and inflammatory tissue damage.
José Lourenço Reis +5 more
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Molecular Characterization of the Porcine TIM‐3 Gene
Scandinavian Journal of Immunology, 2010AbstractTIM‐3 is a member of the TIM (T‐cell immunoglobulin domain and mucin domain) family, which plays an important role in TH1 responses and autoimmune diseases. In this study, we cloned and characterized the porcine TIM‐3 gene. Real‐time PCR showed little expression of porcine TIM‐3 in muscle and stomach, low expression in kidney, brain, stomach ...
W, Zhao, Y, Li, Z, Wang, K, Li, S, Yang
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Tissue Antigens, 2015
AbstractImmune dysfunction is the main characteristic of sepsis. T cell Ig and mucin domain protein 3 (Tim‐3) on the monocytes has been reported to promote immune homeostasis during sepsis, but the influences of plasm soluble Tim‐3 (sTim‐3) on the immune system during sepsis remain unknown.
F, Ren +10 more
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AbstractImmune dysfunction is the main characteristic of sepsis. T cell Ig and mucin domain protein 3 (Tim‐3) on the monocytes has been reported to promote immune homeostasis during sepsis, but the influences of plasm soluble Tim‐3 (sTim‐3) on the immune system during sepsis remain unknown.
F, Ren +10 more
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Tim-3 Regulation of Cancer Immunity
2014Chronic unrelenting immune responses can lead to immunopathology that can be fatal. Consequently, the immune system has evolved both molecular and cellular mechanisms that serve to contract active immune responses and restore immune homeostasis. Molecular mechanisms include the upregulation of inhibitory or immune checkpoint receptors on T cells post ...
Kaori Sakuishi, Ana C. Anderson
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