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Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

Nature Immunology, 2003
T helper type 1 (T(H)1) immune responses are central in cell-mediated immunity, and a T(H)1-specific cell surface molecule called Tim-3 (T cell immunoglobulin domain, mucin domain) has been identified. Here we report the identification of a secreted form of Tim-3 that contains only the immunoglobulin (Ig) variable (V) domain of the full-length molecule.
Catherine A, Sabatos   +9 more
openaire   +2 more sources

Discovery of TIM-3: Beyond a Th1 Regulator

The Journal of Immunology
Abstract This Pillars of Immunology article is a commentary on “Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease,” a pivotal article written by L. Monney, C. A. Sabatos, J. L. Gaglia, A. Ryu, H. Waldner, T. Chernova, S. Manning, E. A. Greenfield, A. J. Coyle, R. A. Sobel, G. J.
openaire   +2 more sources

Tim-3

2014
Kiera Clayton, Mario Ostrowski
openaire   +1 more source

TIM-3 regulates microglial function

Nature Reviews Drug Discovery
openaire   +1 more source

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