Results 301 to 310 of about 17,630,315 (317)

Discovery of Small-Molecule TIM-3 Inhibitors for Acute Myeloid Leukemia Using Pharmacophore-Based Virtual Screening.

Journal of Medicinal Chemistry, 2023
T-cell immunoglobulin and mucin domain 3 (TIM-3) is a negative immune checkpoint that represents a promising target for cancer immunotherapy. Although encouraging results have been observed for TIM-3 inhibition in the context of acute myeloid leukemia ...
Somaya A. Abdel-Rahman, Valerij Talagayev, Szymon Pach, Gerhard Wolber, Moustafa T. Gabr   +4 more
semanticscholar   +1 more source

Role of TIM-3 in ovarian cancer

Clinical and Translational Oncology, 2017
Evidences have suggested that immunotherapy for ovarian cancer is effective. Immune checkpoints have emerged in the field of cancer immunotherapy. Multiple studies have shown negative regulation of TIM-3 expression on CD4+ and CD8+ T cells and other immunocytes.
Y, Xu, H, Zhang, Y, Huang, X, Rui, F, Zheng   +4 more
openaire   +2 more sources

Importance of photophosphatidylserine and Tim-3 in photoimmunotherapy

RSC Medicinal Chemistry, 2022
Natural killer (NK) cells help regulate autoimmune reactions, but overactivation causes harm.
Akshansh Sharma, Arun Kumar, Sadanand Pandey, Deepak Kumar   +3 more
openaire   +2 more sources

Tim-3 expression in human kidney allografts

Transplant Immunology, 2007
Tim-3 was recently described as a Th1-specific molecule, participating in the regulation of immune responses and in the induction of allograft tolerance. Here, we studied Tim-3 mRNA expression together with molecular markers of T-cell activation and cytotoxicity, in rejected human kidney grafts.Twenty human kidney grafts that had undergone nephrectomy ...
Ponciano, Viviane C., Renesto, Paulo G., Nogueira, Eliana, Rangel, Erika B., Cenedeze, Marcos A., Franco, Marcello F., Camara, Niels O. S., Pacheco-Silva, Alvaro   +7 more
openaire   +3 more sources

LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation.

Immunity
LAG-3, TIM-3, and TIGIT comprise the next generation of immune checkpoint receptors being harnessed in the clinic. Although initially studied for their roles in restraining T cell responses, intense investigation over the last several years has started ...
Nicole Joller, A. C. Anderson, Vijay K. Kuchroo   +2 more
semanticscholar   +1 more source

Identification of Different Form Tim-3 Proteins by a Unique Set of Tim-3 Monoclonal Antibodies

Journal of Immunotherapy, 2019
T-cell immunoglobulin and mucin domain-3 (Tim-3) has been suggested to be a critical immune checkpoint target for cancer immunotherapy. However, limited progress with Tim-3 immunotherapy has been achieved over the last decade due to the lack of specific Tim-3 monoclonal antibodies.
Zhuocai, Wang, Guangning, Yan, Wenzhi, Cui, Feng, Gao, Jing, Chen, Luqiao, Luo, Minghui, Zhang, Zhi, Li   +7 more
openaire   +2 more sources

Molecular Characterization of the Porcine TIM‐3 Gene

Scandinavian Journal of Immunology, 2010
AbstractTIM‐3 is a member of the TIM (T‐cell immunoglobulin domain and mucin domain) family, which plays an important role in TH1 responses and autoimmune diseases. In this study, we cloned and characterized the porcine TIM‐3 gene. Real‐time PCR showed little expression of porcine TIM‐3 in muscle and stomach, low expression in kidney, brain, stomach ...
W, Zhao, Y, Li, Z, Wang, K, Li, S, Yang
openaire   +2 more sources

Plasma soluble Tim‐3 emerges as an inhibitor in sepsis: sepsis contrary to membrane Tim‐3 on monocytes

Tissue Antigens, 2015
AbstractImmune dysfunction is the main characteristic of sepsis. T cell Ig and mucin domain protein 3 (Tim‐3) on the monocytes has been reported to promote immune homeostasis during sepsis, but the influences of plasm soluble Tim‐3 (sTim‐3) on the immune system during sepsis remain unknown.
F, Ren, J, Li, X, Jiang, K, Xiao, D, Zhang, Z, Zhao, J, Ai, C, Hou, Y, Jia, G, Han, L, Xie   +10 more
openaire   +2 more sources

Tim-3 Regulation of Cancer Immunity

2014
Chronic unrelenting immune responses can lead to immunopathology that can be fatal. Consequently, the immune system has evolved both molecular and cellular mechanisms that serve to contract active immune responses and restore immune homeostasis. Molecular mechanisms include the upregulation of inhibitory or immune checkpoint receptors on T cells post ...
Kaori Sakuishi, Ana C. Anderson
openaire   +1 more source

Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

Nature Immunology, 2003
T helper type 1 (T(H)1) immune responses are central in cell-mediated immunity, and a T(H)1-specific cell surface molecule called Tim-3 (T cell immunoglobulin domain, mucin domain) has been identified. Here we report the identification of a secreted form of Tim-3 that contains only the immunoglobulin (Ig) variable (V) domain of the full-length molecule.
Catherine A, Sabatos, Sumone, Chakravarti, Eugene, Cha, Anna, Schubart, Alberto, Sánchez-Fueyo, Xin Xiao, Zheng, Anthony J, Coyle, Terry B, Strom, Gordon J, Freeman, Vijay K, Kuchroo   +9 more
openaire   +2 more sources