Results 151 to 160 of about 5,137,492 (319)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Application of time-frequency domain and deep learning fusion feature in non-invasive diagnosis of congenital heart disease-related pulmonary arterial hypertension. [PDF]
MethodsX, 2023 Ma P +5 more
europepmc +1 more source
Characterization and computation of canonical tight windows for Gabor frames
, 2000 Let $(g_{nm})_{n,m\in Z}$ be a Gabor frame for $L_2(R)$ for given window $g$. We show that the window $h^0=S^{-1/2} g$ that generates the canonically associated tight Gabor frame minimizes $\|g-h\|$ among all windows $h$ generating a normalized tight ...
Janssen, A. J. E. M, Strohmer, Thomas
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Time–Frequency Domain Seismic Signal Denoising Based on Generative Adversarial Networks [PDF]
Ming Wei, Xinlei Sun, Jianye Zong
openalex +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
, 2016 In wireless networks, interferences between trans- missions are modelled either in time or frequency domain. In this article, we jointly analyze interferences in the time- frequency domain using a stochastic geometry model assuming the total time ...
Brossier, Jean-Marc +4 more
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source