Results 41 to 50 of about 2,570,440 (302)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Summary Report of The First International Competition on Computational Models of Argumentation [PDF]
, 2016 Computational models of argumentation are an active research discipline within Artificial Intelligence that has grown since the beginning of the 1990s (Dung 1995).
Cerutti, Federico +5 more
core +4 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Back to the future in NHS reform [PDF]
, 2005 PURPOSE - In the mid 1990s the NHS ‘did’ competition, in the mid 2000s the NHS is ‘doing’ choice. This paper aims to cut through the rhetoric, highlight the differences and parallels between then and now and identify if these differences will have a ...
Warwick, P.
core +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Past and Future in the Evolution of US Policy in the Field of Competition [PDF]
Annals of Dunarea de Jos University. Fascicle I : Economics and Applied Informatics, 2010 American competition policy is based on three normative acts: The Sherman Act, The Clayton Act and the Federal Trade Commission Act, even though they will see many amendments and different interpretations with time.
Eduard IONESCU
doaj
Deep Evolution Algorithm Under Competitive and Cooperative Behavior
Jisuanji kexue yu tansuo, 2020 Combining depth with evolutionary algorithms, a deep evolutionary algorithm, the group competition cooperation optimization (GCCO) algorithm, is proposed.
CHEN Haijuan, FENG Xiang, YU Huiqun
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Is There Really an Inverted U-shaped Relation Between Competition and R&D? [PDF]
We test whether predictions of the Aghion and Howitt (2004) model are supported by firm level data. In particular, we analyze if there is an inverted U-shaped relation between competition and R&D.
Gustavsson Tingvall, Patrik +1 more
core +3 more sources