Results 81 to 90 of about 11,508,189 (315)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Delay differential equation models for real-time dynamic substructuring

, 2005
Real-time dynamic substructuring is a testing technique that models an entire system through the combination of an experimental test piece, representing part of the system, with a numerical model of the rest of the system.
Wagg, DJ, Wallace, MI, Neild, SA, Sieber, J, Krauskopf, B   +4 more
core  

Input-Output Representation and Identifiability of Delay Parameters for Nonlinear Systems with Multiple Time-Delays

, 2009
We have analyzed the identifiability of time-lag parameters in nonlinear delay systems using an algebraic framework. The identifiability is determined by the form of the system's input-output representation.
Wennberg, Bernt, Bernt Wennberg, Wennberg, Bernt,, Anguelova, Milena, Milena Anguelova, Anguelova, Milena,   +5 more
core   +1 more source

Consensus Analysis of Second-Order Multi-Agent Networks With Sampled Data and Packet Losses

IEEE Access, 2016
In this paper, we address the consensus problem of second-order multi-agent system with sampled-data and packet losses. A Bernoulli stochastic variable is used to characterize the random packet losses in second-order multi-agent system with sampled-data ...
Wenxia Cui, Yang Tang, Jian-An Fang, Jurgen Kurths   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Stability Analysis of Nonlinear Time–Delayed Systems with Application to Biological Models

International Journal of Applied Mathematics and Computer Science, 2017
In this paper, we analyse the local stability of a gene-regulatory network and immunotherapy for cancer modelled as nonlinear time-delay systems. A numerically generated kernel, using the sum-of-squares decomposition of multivariate polynomials, is used ...
Kruthika H.A., Mahindrakar Arun D., Pasumarthy Ramkrishna   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Robust Sample-and-Hold Stabilization for Nonlinear Retarded Systems

, 2016
In this paper we deal with the stabilization in the sample and hold sense of retarded systems affected by actuation disturbances and observation errors.
DI FERDINANDO, MARIO, PEPE, PIERDOMENICO
core   +1 more source

Positivity of Continuous-Time Descriptor Systems With Time Delays [PDF]

, 2014
This technical note is concerned with positivity characteristic of continuous-time descriptor systems with time delays. First, a set of necessary and sufficient conditions is presented to check the property.
Yan, Xinggang, Zhang, Youmei, Tanaka, Tamaki, Zhang, Qingling   +3 more
core   +1 more source

Hopf Bifurcation of a Delayed Predator Model with Prey Refuge and Fear Effect

Journal of Harbin University of Science and Technology
In order to investigate the effects of time delay on the dynamical behavior of prey and predator with prey refuge and fear effect, a time-delay predator-prey model with prey refuge and fear effect is established.
YUAN Hailong, ZHANG Jiaxiang, ZHANG Conghui   +2 more
doaj   +1 more source