Results 91 to 100 of about 11,508,189 (315)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Maximum Principle for Time-Delay Backward Doubly Stochastic Optimal Control Problems Under Partial Information

Mathematics
This paper investigates the optimal control problem of time-delay backward doubly stochastic systems under partial information. Partial information widely exists in practical control systems due to monitoring constraints, communication delays, and data ...
Jie Xu
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Analysis of delay fluctuationsin two-way time transfer earth stations

, 2012
[[abstract]]The delay fluctuations in earth stations have become the main source of instability that degrades the accuracy of two-way satellite time and frequency transfer.
W. H. Tseng;H. T. Lin;P. C. Chang;S. Y. Lin;K. M. Feng
core  

Eigen-Analysis Considering Time-Delay and Data-Loss of WAMS and ITS Application to WADC Design Based on Damping Torque Analysis

Energies, 2018
Data-loss from wide-area measurement systems (WAMS) is a stochastic event and eigenvalues of power systems containing data-loss cannot be calculated directly.
Tao Zhou, Zhong Chen, Siqi Bu, Haoran Tang, Yi Liu   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

On discretizing the semigroup of solution operators for linear time invariant - time delay systems

, 2010
On discretizing the semigroup of solution operators for linear time invariant - time delay ...
Vermiglio R., Breda D., MASET, STEFANO
core  

Editorial: From Structure to Function in Neuronal Networks: Effects of Adaptation, Time-Delays, and Noise

Frontiers in Systems Neuroscience, 2022
Joana Cabral, Joana Cabral, Joana Cabral, Viktor Jirsa, Oleksandr V. Popovych, Alessandro Torcini, Serhiy Yanchuk, Serhiy Yanchuk   +7 more
doaj   +1 more source

Electromagnetic torque analysis-based method for performance evaluation and optimisation of closed-loop CPS regarding small signal stability

IET Cyber-Physical Systems, 2018
Low frequency oscillation occurs frequently in the smart grid, which threatens the security and stability of the physical system. Wide-area damping controller (WADC), which belongs to cyber system, can effectively ...
Yibiao Sheng, Tao Lin, Rusi Chen, Baoping Chen, Guili Ding, Xialing Xu, Chang Xie, Lin Liu   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source