Results 101 to 110 of about 381,914 (292)

An Online Updating Approach for Testing the Proportional Hazards Assumption with Streams of Big Survival Data

, 2018
The Cox model, which remains as the first choice in analyzing time-to-event data even for large datasets, relies on the proportional hazards assumption. When the data size exceeds the computer memory, the standard statistics for testing the proportional ...
Schifano, Elizabeth D., Wang, HaiYing, Xue, Yishu, Yan, Jun   +3 more
core   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

A time-dependent predictive model for cardiocerebral vascular events in chronic hemodialysis patients: insights from a prospective study

Frontiers in Medicine
ContextThe conventional risk factors for cardiocerebral vascular events (CVCs) in non-Hemodialysis (HD) patients cannot be directly applied to HD patients due to the unique characteristics of this population.
Haowen Zhong, Haowen Zhong, Mengbi Zhang, Mengbi Zhang, Yingye Xie, Yingye Xie, Yuqin Qin, Na Xie, Na Xie, Yuqiu Ye, Yuqiu Ye, Heng Li, Heng Li, Hongquan Peng, Xun Liu, Xiaoyan Su, Xiaoyan Su, Shaohong Li, Shaohong Li   +18 more
doaj   +1 more source

Penalized variable selection procedure for Cox models with semiparametric relative risk

, 2010
We study the Cox models with semiparametric relative risk, which can be partially linear with one nonparametric component, or multiple additive or nonadditive nonparametric components.
Du, Pang, Liang, Hua, Ma, Shuangge
core   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Asymptotic theory for the Cox model with missing time-dependent covariate

, 2006
The relationship between a time-dependent covariate and survival times is usually evaluated via the Cox model. Time-dependent covariates are generally available as longitudinal data collected regularly during the course of the study.
Dupuy, Jean-François, Grama, Ion, Mesbah, Mounir   +2 more
core   +2 more sources

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

The Effect of Time-dependent Prognostic Factors on Survival of Non-Small Cell Lung Cancer using Bayesian Extended Cox Model

علوم بهداشتی ایران, 2020
Background: Lung cancer is one of the most common cancers around the world. The aim of this study was to use Extended Cox Model (ECM) with Bayesian approach to survey the behavior of potential time-varying prognostic factors of Non-small cell lung cancer.
Vida Pahlevani, Hossein Fallahzadeh, Nima Pahlevani, Abolfazl Nikpour, Morteza Mohammadzadeh   +4 more
doaj  

Dynamic Predictions with Time-Dependent Covariates in Survival Analysis using Joint Modeling and Landmarking [PDF]

, 2013
A key question in clinical practice is accurate prediction of patient prognosis. To this end, nowadays, physicians have at their disposal a variety of tests and biomarkers to aid them in optimizing medical care.
Andrinopoulou, Eleni-Rosalina, Lesaffre, Emmanuel, Molenberghs, Geert, Murawska, Magdalena, Rizopoulos, Dimitris, Takkenberg, Johanna J. M.   +5 more
core