Results 101 to 110 of about 13,838,030 (309)

Distributed-memory parallelization of an explicit time-domain volume integral equation solver on Blue Gene/P [PDF]

, 2012
Two distributed-memory schemes for efficiently parallelizing the explicit marching-on in-time based solution of the time domain volume integral equation on the IBM Blue Gene/P platform are presented.
Cheeseman, M, Bağcı, H, Al-Jarro, A
core  

A Novel Piecewise Linear Recursive Convolution Approach for Dispersive Media Using the Finite-Difference Time-Domain Method [PDF]

, 2014
Two novel methods for implementing recursively the convolution betweenthe electric field and a time dependent electric susceptibility function inthe finite-difference time domain (FDTD) method are presented.
Giannakis, Iraklis, Giannopoulos, Antonios; id_orcid, Giannopoulos, Antonios   +2 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Asymptotic Performance Analysis of Time-Frequency-Domain Spread MC DS-CDMA Systems Employing MMSE Multiuser Detection [PDF]

, 2010
In this contribution the asymptotic signal-to-interference-plus-noise ratio (SINR) performance of multicarrier direct-sequence code-division multiple-access systems employing time-frequency-domain spreading, i.e., of the TF/MC DS-CDMA systems, is studied,
Zhang, Youguang, Yang, Lie-Liang, Lie-Liang Yang, Peng Pan, Youguang Zhang, Pan, Peng   +5 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Terahertz Time Domain Spectrometer

, 2014
In the framework of the European Metrology Research Program Project NEW-07 “Microwave and Terahertz metrology for homeland security”, a Time Domain Spectrometer working up to about 3 THz has been realized.
OBERTO, LUCA, BISI, MARCO
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Accurate Behavioral Simulator of All-Digital Time-Domain Smart Temperature Sensors by Using SIMULINK

Sensors, 2016
This study proposes a new behavioral simulator that uses SIMULINK for all-digital CMOS time-domain smart temperature sensors (TDSTSs) for performing rapid and accurate simulations. Inverter-based TDSTSs offer the benefits of low cost and simple structure
Chun-Chi Chen, Chao-Lieh Chen, You-Ting Lin   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source