Results 61 to 70 of about 2,678,584 (258)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Time to Frequency Domain Analysis of Narrow Band Antennas

International Journal of Antennas and Propagation, 2017
This paper presents system modeling of three different single band antennas using the singularity expansion method (SEM). To acquire the accurate physical complex poles and the corresponding residues of the narrow band antenna model, an enhanced Matrix ...
Sajjad Ur Rehman, Majeed A. S. Alkanhal
doaj   +1 more source

Time–frequency analysis of bivariate signals

Applied and Computational Harmonic Analysis, 2019
Many phenomena are described by bivariate signals or bidimensional vectors in applications ranging from radar to EEG, optics and oceanography. The time-frequency analysis of bivariate signals is usually carried out by analyzing two separate quantities, e.g. rotary components.
Flamant, Julien, Le Bihan, Nicolas, Chainais, Pierre   +2 more
openaire   +5 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Diagnosis of industrial gearboxes condition by vibration and time-frequency, scale-frequency, frequency-frequency analysis

Metalurgija, 2012
In the article methods of vibroacoustic diagnostics of high-power toothed gears are described. It is shown below, that properly registered and processed acoustic signal or vibration signal may serve as an explicitly interpreted source of diagnostic ...
P. Czech
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

New method for detecting site liquefaction trigger time based on strong motion records

Yantu gongcheng xuebao
The mechanical properties of soils undergo significant changes before and after liquefaction during an earthquake, which consequently lead to a qualitative shift in surface and structural damage mechanisms.
YAN Zhuowen 1, YUAN Xiaoming 1, YUAN Jinyuan 2, LI Ruishan 1, WU Xiaoyang 1, YANG Yang 3, LIU Hanlong 3
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A novel time-frequency multilayer network for multivariate time series analysis

New Journal of Physics, 2018
Unveiling complex dynamics of natural systems from a multivariate time series represents a research hotspot in a broad variety of areas. We develop a novel multilayer network analysis framework, i.e.
Weidong Dang, Zhongke Gao, Dongmei Lv, Mingxu Liu, Qing Cai, Xiaolin Hong   +5 more
doaj   +1 more source