Results 101 to 110 of about 2,232,503 (310)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A time-frequency approach for spike detection

, 2003
This paper presents a new time frequency based spike detection technique. As spikes are broadband events with high instantaneous energy, they tend to have a larger energy than the background at high frequencies.
Boashash, Boualem, Hassanpour, Hamid, Mesbah, Mostefa   +2 more
core   +1 more source

Measuring. Monitoring. Management. Control

Измерение, мониторинг, управление, контроль
Background. This research relates to the field of aircraft location using an information and measurement system of electrostatic location. To locate aircraft, it is necessary to determine the signs of an electrostatic signal from several sensors ...
Yu.M. Scryabin
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

WVD‐GAN: A Wigner‐Ville distribution enhancement method based on generative adversarial network

IET Radar, Sonar & Navigation
Time‐frequency analysis based on Wigner‐Ville distribution (WVD) plays a significant role in analysing non‐stationary signals, but it is susceptible to interference from cross‐terms (CTs) for multi‐component signals.
Daying Quan, Feitao Ren, Xiaofeng Wang, Mengdao Xing, Ning Jin, Dongping Zhang   +5 more
doaj   +1 more source

Experimental study on time-frequency characteristics of self-excited pulsed jet striking force in self-absorbing annular-air fluid type

Meitan kexue jishu
In order to quantitatively analyze the striking force of self-absorbing annular-air fluidic self-excited pulsed jet, and to improve the impact performance of downward-facing orifice submerged water jets, a high-frequency striking force test system of ...
Weiqin ZUO, Shengjie WU, Yanwei LIU, Liqun LONG, Haojie JIA, Jian MIAO, Shixi ZHANG   +6 more
doaj   +1 more source

Analysis of active interference on terminal guidance radar interference [PDF]

Zhihui kongzhi yu fangzhen
To investigate the effectiveness of active jamming against terminal guidance radar, this paper conducts theoretical modeling and analysis of the jamming capabilities.
JIN Zirong, SUN Haiwen, YANG Huadong, WANG Zhaochen
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Applications of statistics in flood frequency analysis

, 2012
Estimation of the probability of occurrence of future flood events at one or more locations across a river system is frequently required for the design of bridges, culverts, spillways, dams and other engineering works.
Ahmad, Muhammad Idrees
core