Results 151 to 160 of about 2,252,514 (265)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Adenotonsillectomy is associated with increased risk and disease activity in pediatric-onset multiple sclerosis. [PDF]

Mult Scler
Chang G, Nasr Z, Schoeps VA, Virupakshaiah A, Zamvil SS, Moseley CE, Sabatino JJ, Chong J, Graves JS, Waltz M, Rodriguez M, Tillema JM, Chitnis T, Rensel M, Abrams AW, Krupp L, Waldman AT, Mar S, Schreiner T, Rose J, Casper TC, Waubant E.   +21 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Testosterone status and bone mineral density in Finnish male endurance athletes: Baseline associations and 1-year follow-up. [PDF]

Physiol Rep
Wagner A, Mjøsund K, Komonen R, Hackney AC, Ihalainen JK.   +4 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Cardiopulmonary resuscitation in donation after brain death donors aged ≥65 years: impact on outcomes after kidney transplantation - a multi-center study. [PDF]

Transpl Int
Süsal CC, Bachmann Q, Kälble F, Mahler CF, Ott M, Heymer J, Braunisch M, Assfalg V, Dippon J, Heemann U, Renders L, Schwenger V, Echterdiek F.   +12 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Chemoport-related right innominate vein stenosis in patients with colorectal cancer: A retrospective risk factor analysis. [PDF]

PLoS One
Kim J, Lee JS, Chee CG, Woo J, Kim Y, Lee E, Lee JW, Choi SI.   +7 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Children with speech and language delay aged 2-10 Years in Palestine: A case-control study of socio-demographic, biological, familial, and environmental factors. [PDF]

SAGE Open Med
Al-Lahham S, Dweikat R, Nazzal T, Abo Shama N, Bishara A, Khaskia N, Jbara M, Haj Yahia A, Ghanim M, Dwikat M, Abuawad M, Alkhaldi S, Hamdan A, Abdel Jalil W, El-Lahham L, Rabayaa M, Alqub M.   +16 more
europepmc   +1 more source