Results 211 to 220 of about 6,954,643 (310)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Recurrent episodes of pneumonia are associated with worse lung function in people with HIV. [PDF]

PLoS One
Walderich SJ, Fitzpatrick-Collins J, Bates A, Zhang MH, Branchini J, Gardner K, Bhide S, Jan A, Abelman R, Byanova KL, Huang L.   +10 more
europepmc   +1 more source

TIME HISTORY ANALYSIS OF RCC BUILDING USING ETABS SOFTWARE

International Research Journal of Modernization in Engineering Technology and Science, 2023
openaire   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Developing and Validating a Coding Scheme for Clinical Reasoning in History Taking Using Generative AI-Based Virtual Patients: Systematic Text Condensation Approach.

JMIR Med Educ
Chen N, Tang L, Liu Y, Lin C, Li Z, Shi C, Xia M, Gasevic D, Gasevic D, Zheng J, Fan Y, Li X.   +11 more
europepmc   +1 more source

Cancer genetic testing uptake in the primary care setting: Patient perspectives on barriers and facilitators throughout the testing process. [PDF]

J Genet Couns
Theoryn TN, Beers F, Dusic EJ, Wang C, Cameron D, Harris H, Knerr S, Swisher EM, Trinidad SB.   +8 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Risk factors for spontaneous abortion following hepatitis E vaccination during and shortly before pregnancy: Further analysis from a cluster-randomized trial. [PDF]

PLoS One
Aziz AB, Ahmmed F, Haile K, Kering K, Dudman S, Julin CH, Øverbø J, Khan AI, Akter A, Ongadi BA, Ngugi B, Mbae CK, Mesfin E, Chowdhury F, Khanam F, Lee JE, Im J, Bundi MM, Firoj MG, Islam MT, Mwangi M, Rickett NY, Ara SI, Behute MG, Park SE, Agampodi S, Kariuki S, Kanungo S, Kim DR, Qadri F, Zaman K, Clemens JD.   +31 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Effect of A History of Anxiety and Depression on Patient-Reported Outcomes After Hip Arthroscopy at 2-Year Follow-up. [PDF]

Orthop J Sports Med
Quinn M, Morrissey P, Pisani C, Marquez-Garcia J, Ahn B, Zhang H, Milner JD, Wendolowski SF, Bruni DF, Tabaddor R.   +9 more
europepmc   +1 more source