Results 81 to 90 of about 743,834 (304)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Togetherness in musical interaction [version 1; peer review: 2 approved, 3 approved with reservations]

open access: yesRoutledge Open Research
Playing music as part of a group is challenging, but also rewarding. What factors come together to maximize rewarding group playing experiences? How do feelings of enjoyment, frustration, and social (dis)connection shape group performance as it unfolds ...
Laura Bishop
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Togetherness in musical interaction [version 2; peer review: 3 approved, 3 approved with reservations]

open access: yesRoutledge Open Research
This paper presents a model of musical togetherness (MT), defined as the sense of musical connection that arises during real-time interaction and results in feelings of social connection, pleasure, and trust. The model comprises three layers.
Laura Bishop
doaj   +1 more source

Where Are the Months? Mental Images of Circular Time in a Large Online Sample

open access: yesFrontiers in Psychology, 2019
People may think about time by mentally imaging it in some spatial form, or as “spacetime.” In an online survey, 76,922 Norwegian individuals positioned two dots corresponding to the months of December and March on what they imagined to be their ...
Bruno Laeng, Bruno Laeng, Anders Hofseth
doaj   +1 more source

Work capacity and surgical output for cataract in the national capital region of Delhi and neighbouring districts of north India. [PDF]

open access: yes, 2008
OBJECTIVES: To ascertain time taken for cataract surgery by ophthalmologists in the National Capital Region of Delhi and neighbouring districts, to determine what work output is feasible with the available ophthalmologists. METHODS: The time-motion study
Gupta, SK   +3 more
core  

MoSculp: Interactive Visualization of Shape and Time

open access: yes, 2018
We present a system that allows users to visualize complex human motion via 3D motion sculptures---a representation that conveys the 3D structure swept by a human body as it moves through space.
Dekel, Tali   +7 more
core   +1 more source

Time-motion and heart-rate characteristics of adolescent female foil fencers [PDF]

open access: yes, 2015
Purpose: The aims of this study was to understand the time-motion and heart-rate characteristics of adolescent female foil fencing, explore the differences between the 5-touch and 15-touch bouts and compare these results with previous analysis of elite ...
Wylde, Matthew James, Yong, Low Chee
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

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