Results 141 to 150 of about 36,815 (253)

1,7‐Digallatetracarborane: Between Nucleophilic closo‐Cluster and “Inverse Sandwich” Digallylene

Angewandte Chemie, EarlyView.
A dianionic π‐ligand is used to make a Janus‐type twofold complex with low‐valent gallium Ga(+I). The resulting compound can be seen as and reveals the reactivity of both: a Wade‐type closo‐carborane cluster with nucleophilic Ga‐sites, as well as π‐ligand stabilized Ga(I) atoms in an inverse sandwich compound.
Julijan Sarcevic, Tobias Heitkemper, Niklas Mehner, Maximilian Kubis, Christian P. Sindlinger   +4 more
wiley   +2 more sources

Probing the modulation of enzyme kinetics by multi-temperature, time-resolved serial crystallography

Nature Communications
The vast majority of protein structures are determined at cryogenic temperatures, which are far from physiological conditions. Nevertheless, it is well established that temperature is an essential thermodynamic parameter for understanding the ...
Eike C. Schulz, Andreas Prester, David von Stetten, Gargi Gore, Caitlin E. Hatton, Kim Bartels, Jan-Philipp Leimkohl, Hendrik Schikora, Helen M. Ginn, Friedjof Tellkamp, Pedram Mehrabi   +10 more
doaj   +1 more source

Time-resolved crystallography reveals allosteric communication aligned with molecular breathing

, 2019
A comprehensive understanding of protein function demands correlating structure and dynamic changes. Using time-resolved serial synchrotron crystallography, we visualized half-of-the-sites reactivity and correlated molecular-breathing motions in the ...
Mehrabi, Pedram, Müller-Werkmeister, Henrike M., Müller-Werkmeister, Henrike (Prof. Dr.), Dsouza, Raison, Schulz, Eike C., Miller, R. J. Dwayne, Tellkamp, Friedjof, Pai, Emil F.   +7 more
core   +1 more source

Enhancing Enzyme Activity With Mutation Combinations Guided by Few‐Shot Learning and Causal Inference

Angewandte Chemie, EarlyView.
We present an integrated workflow that predicts activity‐enhancing mutation combinations from minimal experimental data. By proposing in vivo unit yield (yield/expression) as a surrogate for kcat/Km through causal inference, and visualizing local activity landscape, it effectively guides product yield improvement. ABSTRACT Designing enzyme sequences to
Lin Guo, Xiaoguang Yan, Yali Lu, Shengxin Nie, Mingyue Ge, Yukun Li, Weiguo Li, Xiaochun Zhang, Dongmei Liang, Yihan Zhao, Hongxiao Tan, Xiling Chen, Shilong Fan, Yefeng Tang, Jianjun Qiao, Boxue Tian   +15 more
wiley   +2 more sources

Cyclo‐Polyproline: Chameleonic All‐Peptide Macrocycles With Induced‐Fit Host‐Guest Recognition

Angewandte Chemie, EarlyView.
Macrocycles served as the genesis of supramolecular chemistry, advancing synthetic, separation, and materials fields. Despite their utility, they typically lack synthetic control. This work establishes a robust platform for all‐peptide macrocycles capable of host‐guest complexation and chameleonic behavior.
Camilla Di Girolamo, Patricia C. Fleming, Caroline R. Kwawu, Amanda R. Guimarães, Jimmy Muldoon, Julia Bruno‐Colmenarez, Yannick Ortin, Michael R. Probert, Felipe Fantuzzi, Aniello Palma   +9 more
wiley   +2 more sources

Infrared protein crystallography

, 2011
Ravelli, Raimond B. G., Sage, J. Timothy, McGeehan, John, Zhang, Yunbin, Van Thor, Jasper J., Weik, Martin   +5 more
core   +1 more source

Dual Activation of H2 and CO2 by a Pincer‐Type Ni–Zn Heterobimetallic Complex

Angewandte Chemie, EarlyView.
A bimetallic Ni−Zn complex performs sequential activations of H2 (1 equiv) and CO2 (2 equiv). This bimetallic cooperativity is attributed to the weak Lewis acidic nature of Zn(II), which promotes fluxional ligand binding. Namely, an X‐type ligand at Ni, where X is hydride or formate, toggles between two different binding modes: bridging Zn(μ‐X)Ni and ...
Krishnendu Dey, Matthias Borowski, Gregor Schnakenburg, Connie C. Lu   +3 more
wiley   +2 more sources

Mixing injector enables time-resolved crystallography with high hit rate at X-ray free electron lasers. [PDF]

Struct Dyn, 2016
Calvey GD, Katz AM, Schaffer CB, Pollack L.   +3 more
europepmc   +1 more source

Capturing structural intermediates in an animal-like cryptochrome photoreceptor by time-resolved crystallography. [PDF]

Sci Adv
Maestre-Reyna M, Hosokawa Y, Wang PH, Saft M, Caramello N, Engilberge S, Franz-Badur S, Gusti Ngurah Putu EP, Nakamura M, Wu WJ, Wu HY, Lee CC, Huang WC, Huang KF, Chang YK, Yang CH, Fong MI, Lin WT, Yang KC, Ban Y, Imura T, Kazuoka A, Tanida E, Owada S, Joti Y, Tanaka R, Tanaka T, Kang J, Luo F, Tono K, Kiontke S, Korf L, Umena Y, Tosha T, Bessho Y, Nango E, Iwata S, Royant A, Tsai MD, Yamamoto J, Essen LO.   +40 more
europepmc   +1 more source

Time-resolved monochromatic synchrotron crystallography of a plant photoreceptor domain

, 2019
La cristallographie résolue dans le temps (TRX) permet l’identification à l’échelle quasi atomique des changements structuraux progressifs au sein d’une protéine lorsqu’elle réalise sa fonction, permettant la constitution de véritables films moléculaires.
Aumonier, Sylvain
core