Results 1 to 10 of about 11,269 (219)
Exploring serial crystallography for drug discovery [PDF]
IUCrJ, 2023 Structure-based drug design is highly dependent on the availability of structures of the protein of interest in complex with lead compounds. Ideally, this information can be used to guide the chemical optimization of a compound into a pharmaceutical drug
A. Dunge +7 more
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Robust error calibration for serial crystallography [PDF]
Structural DynamicsSerial crystallography is an important technique with unique abilities to resolve enzymatic transition states, minimize radiation damage to sensitive metalloenzymes, and perform de novo structure determination from micron sized crystals.
David W. Mittan-Moreau +6 more
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Data reduction in protein serial crystallography [PDF]
IUCrJSerial crystallography (SX) has become an established technique for protein structure determination, especially when dealing with small or radiation-sensitive crystals and investigating fast or irreversible protein dynamics. The advent of newly developed
Marina Galchenkova +9 more
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Room-temperature X-ray fragment screening with serial crystallography [PDF]
Nature CommunicationsStructural insights into protein-ligand interactions are essential for advancing drug development, with macromolecular X-ray crystallography being a cornerstone technique.
Sebastian Günther +13 more
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Approach of Serial Crystallography II [PDF]
Crystals, 2021 Serial crystallography (SX) is an emerging X-ray crystallographic method for determining macromolecule structures. It can address concerns regarding the limitations of data collected by conventional crystallography techniques, which require cryogenic ...
Ki-Hyun Nam
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Serial X-ray Crystallography [PDF]
Crystals, 2022 Serial crystallography (SX) is an emerging technique to determine macromolecules at room temperature. SX with a pump–probe experiment provides the time-resolved dynamics of target molecules.
Ki Hyun Nam
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Serial crystallography is just getting started [PDF]
Structural DynamicsWhen serial crystallography at XFELs was first being developed, it was unclear how it should best be used. Early experiments included studying single crystals, or weak or small crystals, or sample delivery methods that over used crystal material or under
Aaron S Brewster +3 more
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In situ serial crystallography facilitates 96-well plate structural analysis at low symmetry [PDF]
IUCrJThe advent of serial crystallography has rejuvenated and popularized room-temperature X-ray crystal structure determination. Structures determined at physiological temperature reveal protein flexibility and dynamics. In addition, challenging samples (e.g.
Nicolas Foos +13 more
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Droplet microfluidics for time-resolved serial crystallography [PDF]
IUCrJSerial crystallography requires large numbers of microcrystals and robust strategies to rapidly apply substrates to initiate reactions in time-resolved studies.
Jack Stubbs +13 more
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Serial X-ray Crystallography II
Crystals, 2023 Traditional macromolecular crystallography (MX) and recently spotlighted cryogenic electron microscopy (Cryo-EM) techniques have contributed greatly to the development of macromolecule structures and the related fields [...]
Ki Hyun Nam
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