Results 41 to 50 of about 29,886 (251)

Whole-pattern fitting technique in serial femtosecond nanocrystallography

IUCrJ, 2016
Serial femtosecond X-ray crystallography (SFX) has created new opportunities in the field of structural analysis of protein nanocrystals. The intensity and timescale characteristics of the X-ray free-electron laser sources used in SFX experiments ...
Ruben A. Dilanian, Sophie R. Williams, Andrew V. Martin, Victor A. Streltsov, Harry M. Quiney   +4 more
doaj   +1 more source

Continuous Diffraction of Molecules and Disordered Molecular Crystals [PDF]

, 2017
The diffraction pattern of a single non-periodic compact object, such as a molecule, is continuous and is proportional to the square modulus of the Fourier transform of that object. When arrayed in a crystal, the coherent sum of the continuous diffracted
Ayyer, Kartik, Barty, Anton, Chapman, Henry N., Mariani, Valerio, Morgan, Andrew, Oberthuer, Dominik, Pande, Kanupriya, White, Thomas A., Yefanov, Oleksandr M.   +8 more
core   +3 more sources

Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature

IUCrJ, 2022
Room-temperature macromolecular crystallography allows protein structures to be determined under close-to-physiological conditions, permits dynamic freedom in protein motions and enables time-resolved studies.
Tadeo Moreno-Chicano, Leiah M. Carey, Danny Axford, John H. Beale, R. Bruce Doak, Helen M. E. Duyvesteyn, Ali Ebrahim, Robert W. Henning, Diana C. F. Monteiro, Dean A. Myles, Shigeki Owada, Darren A. Sherrell, Megan L. Straw, Vukica Šrajer, Hiroshi Sugimoto, Kensuke Tono, Takehiko Tosha, Ivo Tews, Martin Trebbin, Richard W. Strange, Kevin L. Weiss, Jonathan A. R. Worrall, Flora Meilleur, Robin L. Owen, Reza A. Ghiladi, Michael A. Hough   +25 more
doaj   +1 more source

Graphene-based microfluidics for serial crystallography

Lab on a Chip, 2016
A robust strategy for the incorporation of graphene films as a diffusion barrier in ultra-thin X-ray compatible microfluidic devices.
Sui, Shuo, Wang, Yuxi, Kolewe, Kristopher W., Srajer, Vukica, Henning, Robert, Schiffman, Jessica D., Dimitrakopoulos, Christos, Perry, Sarah L.   +7 more
openaire   +4 more sources

Serial Room Temperature Crystal Loading, Data Collection, and Data Processing of Human Glutaminase C in Complex with Allosteric Inhibitors

Bio-Protocol, 2022
Cancer cells often overexpress glutaminase enzymes, in particular glutaminase C (GAC). GAC resides in the mitochondria and catalyzes the hydrolysis of glutamine to glutamate.
Shawn Milano, D. Szebenyi, Richard Cerione   +2 more
doaj   +1 more source

Dose, exposure time, and resolution in Serial X-ray Crystallography

, 2007
The resolution of X-ray diffraction microscopy is limited by the maximum dose that can be delivered prior to sample damage. In the proposed Serial Crystallography method, the damage problem is addressed by distributing the total dose over many identical ...
Chapman, H. N., Doak, R. B., Fromme, P., Hembree, G., Howells, M., Rez, P., Schmidt, K., Shapiro, D., Spence, J. C. H., Starodub, D., Weierstall, U.   +10 more
core   +1 more source

Femtosecond x-ray diffraction from an aerosolized beam of protein nanocrystals [PDF]

, 2017
We demonstrate near-atomic-resolution Bragg diffraction from aerosolized single granulovirus crystals using an x-ray free-electron laser. The form of the aerosol injector is nearly identical to conventional liquid-microjet nozzles, but the x-ray ...
Adriano, Luigi, Aquila, Andrew, Awel, Salah, Bajt, Saša, Barty, Anton, Beyerlein, Kenneth R., Chapman, Henry N., Horke, Daniel A., Hunter, Mark S., James, Daniel, Kirian, Richard A., Knoska, Juraj, Küpper, Jochen, Mariani, Valerio, Morgan, Andrew, Oberthür, Dominik, Robinson, Joseph S., Rode, Andrei V., Roth, Nils, Roy-Chowdhury, Shatabdi, Tolstikova, Alexandra, Weierstall, Uwe, Wiedorn, Max O., Xavier, P. Lourdu, Yefanov, Oleksandr   +24 more
core   +4 more sources

Entering an era of dynamic structural biology…

BMC Biology, 2018
A recent paper in BMC Biology presents a general method for mix-and-inject serial crystallography, to facilitate the visualization of enzyme intermediates via time-resolved serial femtosecond crystallography (tr-SFX).
Allen M. Orville
doaj   +1 more source

Photoreversible interconversion of a phytochrome photosensory module in the crystalline state. [PDF]

, 2020
A major barrier to defining the structural intermediates that arise during the reversible photointerconversion of phytochromes between their biologically inactive and active states has been the lack of crystals that faithfully undergo this transition ...
Aller, Pierre, Alonso-Mori, Roberto, Batyuk, Alexander, Bhowmick, Asmit, Brewster, Aaron S, Burgie, E Sethe, Butryn, Agata, Clinger, Jonathan A, Cohen, Aina E, Fuller, Franklin D, Gul, Sheraz, Heinemann, Joshua V, Hunter, Mark S, Kern, Jan, Kim, In-Sik, Koglin, Jason E, Miller, Mitchell D, O'Riordan, Lee J, Orville, Allen M, Pham, Cindy C, Phillips, George N, Sauter, Nicholas K, Sutherlin, Kyle D, Vierstra, Richard D, Yachandra, Vittal K, Yano, Junko, Young, Iris D   +26 more
core  

funcX: A Federated Function Serving Fabric for Science

, 2020
Exploding data volumes and velocities, new computational methods and platforms, and ubiquitous connectivity demand new approaches to computation in the sciences.
Akkus I. E., CMS, Forde J., Fox G., Hightower K., Hindman B., Malawski M., Merkel D., Spillner J., Stubbs J., Wang L., Waterman D. G.   +11 more
core   +1 more source