Results 91 to 100 of about 2,354,533 (305)

Ring closing reaction in diarylethene captured by femtosecond electron crystallography [PDF]

, 2013
The photoinduced ring closing reaction in diarylethene, which serves as a modelsystem for understanding reactive crossings through conical intersections, was directly observed with atomic resolution using femtosecond electron diffraction.
Liu, Lai Chung, Jean-Ruel, H., Cooney, R., Liu, L., Miller, R., Gao, Meng, Miller, R. J. Dwayne, Kochman, Michal A., Cooney, Ryan R., Morrison, C., Lu, Cheng, Jean-ruel, Hubert, Gao, M., Morrison, Carole A., Lu, C., Kochman, M.   +15 more
core   +1 more source

QCL-Based Dual-Comb Spectrometer for Multi-Species Measurements at High Temperatures and High Pressures

Sensors, 2020
Rapid multi-species sensing is an overarching goal in time-resolved studies of chemical kinetics. Most current laser sources cannot achieve this goal due to their narrow spectral coverage and/or slow wavelength scanning. In this work, a novel mid-IR dual-
Guangle Zhang, Raphael Horvath, Dapeng Liu, Markus Geiser, Aamir Farooq   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Early Therapeutic Prediction Based on Tumor Hemodynamic Response Imaging: Clinical Studies in Breast Cancer with Time-Resolved Diffuse Optical Spectroscopy

Applied Sciences, 2018
This study reports data from three clinical studies using the time-resolved diffuse optical spectroscopy (TRS) system among breast cancer patients.
Shigeto Ueda, Toshiaki Saeki
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Time-resolved fluorescence studies of nucleotide flipping by restriction enzymes [PDF]

, 2009
Restriction enzymes Ecl18kI, PspGI and EcoRII-C, specific for interrupted 5-bp target sequences, flip the central base pair of these sequences into their protein pockets to facilitate sequence recognition and adjust the DNA cleavage pattern. We have used
Neely, Robert K., Jones, Anita C., Tamulaitis, Gintautas, Kubala, Marta, Neely, Robert K; id_orcid, Chen, Kai, Siksnys, Virginijus, Jones, Anita C   +7 more
core   +1 more source

High time-resolved studies of stick-slip show similar dilatancy to fast and slow earthquakes. [PDF]

Proc Natl Acad Sci U S A, 2023
Hu W, Ge Y, Xu Q, Huang R, Zhao Q, Gou H, McSaveney M, Chang C, Li Y, Jia X, Wang Y.   +10 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Non-invasive depth profiling by space and time-resolved Raman spectroscopy

, 2013
Time-resolved Raman spectroscopy, spatially offset Raman spectroscopy and time-resolved spatially offset Raman spectroscopy (TR-SORS) have proven their capability for the non-invasive profiling of deep layers of a sample.
Jaatinen, Esa, Izake, Emad L., Izake, Emad L, Fredericks, Peter M, Fredericks, Peter, Sundarajoo, Shankaran, Olds, William, Cletus, Biju   +7 more
core   +1 more source