Results 91 to 100 of about 16,727,663 (316)

Circadian-Mediated Regulation of Cardiometabolic Disorders and Aging with Time-Restricted Feeding

Obesity, 2023
Circadian rhythms are present throughout biology, from the molecular level to complex behaviors such as eating and sleeping. They are driven by molecular clocks within cells, and different tissues can have unique rhythms. Circadian disruption can trigger
Jonathan R. Roth, Shweta Varshney, Ruan Carlos Macêdo de Moraes, G. Melkani   +3 more
semanticscholar   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Intermittent fasting and neurocognitive disorders: What the evidence shows

The Journal of Nutrition, Health and Aging
Introduction: Intermittent fasting (IF) has emerged as a potential lifestyle intervention for mitigating cognitive decline and enhancing brain health in individuals with mild to major neurocognitive disorders.
Jordan Beveridge, Allison Montgomery, George Grossberg   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Circadian oscillators in the central extended amygdala are selectively sensitive to restricted feeding but not similarly restricted treats [PDF]

, 2006
When food-access is restricted to a consistent time of day (restricted feeding), rodents reorganize many circadian behaviors around the mealtime. The suprachiasmatic nucleus (SCN) is the master circadian pacemaker, while the oval nucleus of the bed ...
Verwey, Michael A
core   +1 more source

Time-restricted feeding improves aortic endothelial relaxation by enhancing mitochondrial function and attenuating oxidative stress in aged mice

Redox Biology
Age-related endothelial dysfunction is a pivotal factor in the development of cardiovascular diseases, stemming, at least in part, from mitochondrial dysfunction and a consequential increase in oxidative stress.
Madison Milan, Jacob Brown, Colleen L. O’Reilly, M. Bubak, Sharon Negri, Priya Balasubramanian, Arjune S. Dhanekula, Gavin A. Pharaoh, Zeke Reyff, Cade Ballard, Helen Shi, A. Yabluchanskiy, Michael C. Rudolph, Z. Ungvari, D. Marcinek, B. Miller, H. Van Remmen, S. Tarantini   +17 more
semanticscholar   +1 more source

Time-restricted feeding ameliorates MCDD-induced steatohepatitis in mice

, 2023
Abstract Non-Alcoholic Steatohepatitis (NASH) is an inflammatory form of Non-Alcoholic Fatty Liver Disease (NAFLD), closely associated with disease progression, cirrhosis, liver failure, and hepatocellular carcinoma. Time-restricted feeding (TRF) has been shown to decrease body weight and adiposity and improve metabolic outcomes ...
Ik-Rak Jung, Rexford S. Ahima, Sangwon F. Kim   +2 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding

Cell Metabolism
Time-restricted feeding (TRF) has gained attention as a dietary regimen that promotes metabolic health. This study questioned if the health benefits of an intermittent TRF (iTRF) schedule require ketone flux specifically in skeletal and cardiac muscles ...
Ashley S. Williams, Scott B. Crown, Scott P. Lyons, T. Koves, Rebecca J. Wilson, Jordan M. Johnson, D. Slentz, D. P. Kelly, P. Grimsrud, Guo-Fang Zhang, D. Muoio   +10 more
semanticscholar   +1 more source