Results 51 to 60 of about 7,962,398 (254)

Multifractal detrended fluctuation analysis of nonstationary time series [PDF]

, 2002
We develop a method for the multifractal characterization of nonstationary time series, which is based on a generalization of the detrended fluctuation analysis (DFA).
Alados, Amaral, Armin Bunde, Arneodo, Arneodo, Arneodo, Arneodo, Arneodo, Ashkenazy, Ashkenazy, Bacry, Bahar, Barabási, Blesic, Buldyrev, Buldyrev, Bunde, Chen, Eva Koscielny-Bunde, Feder, H.Eugene Stanley, Hausdorff, Hu, Ivanov, Ivanov, Ivanova, Ivanova, Jaffard, Jan W. Kantelhardt, Kantelhardt, Kantelhardt, Koscielny-Bunde, Liu, Makse, Malamud, Mantegna, Muzy, Muzy, Nakao, Ossadnik, Peitgen, Peng, Peng, Shlesinger, Shlomo Havlin, Silchenko, Stephan A. Zschiegner, Talkner, Taqqu, Vandewalle, Vandewalle   +50 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Scaling detection in time series: diffusion entropy analysis [PDF]

, 2002
The methods currently used to determine the scaling exponent of a complex dynamic process described by a time series are based on the numerical evaluation of variance.
C.-K. Peng, G. Trefan, H.A. Makse, H.E. Stanley, I.M. Sokolov, J. Klafter, K. Hu, M. Annunziato, M.F. Shlesinger, M.F. Shlesinger, M.F. Shlesinger, N. Scafetta, Nicola Scafetta, P. Allegrini, P. Grigolini, P. Grigolini, Paolo Grigolini, T. Geisel, T. Geisel   +18 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Expectation-maximization analysis of spatial time series [PDF]

Nonlinear Processes in Geophysics, 2007
Expectation maximization (EM) is used to estimate the parameters of a Gaussian Mixture Model for spatial time series data. The method is presented as an alternative and complement to Empirical Orthogonal Function (EOF) analysis.
K. W. Smith, A. L. Aretxabaleta
doaj  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A Network Analysis of the Impact of the Coronavirus Pandemic on the US Economy: A Comparison of the Return and the Momentum Picture

Entropy
This study examines a cross-correlation analysis of companies included in the S&P 500 Index at three different intervals: before, during, and after the pandemic’s onset.
Janusz Miśkiewicz
doaj   +1 more source