Results 51 to 60 of about 18,151,738 (262)

Feature-Driven Time Series Clustering

, 2021
International audienceThe problem of clustering time series has several applications in real-life contexts, especially in data science and data analytics pipelines.
Ng, Raymond, Bonifati, Angela, Tiano, Donato   +2 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Multivariate Time Series Density Clustering Algorithm Using Shapelet Space [PDF]

Jisuanji kexue yu tansuo
Multivariate time series clustering has become an important research topic in the task of time series analysis. Compared with univariate time series, the research of multivariate time series is more complex and difficult.
SHENG Jinchao, DU Mingjing, SUN Jiarui, LI Yurui
doaj   +1 more source

A Fast Weighted Fuzzy C-Medoids Clustering for Time Series Data Based on P-Splines

Sensors, 2022
The rapid growth of digital information has produced massive amounts of time series data on rich features and most time series data are noisy and contain some outlier samples, which leads to a decline in the clustering effect. To efficiently discover the
Jiucheng Xu, Qinchen Hou, Kanglin Qu, Yuanhao Sun, Xiangru Meng   +4 more
doaj   +1 more source

Time Series Clustering Based on Singularity [PDF]

, 2017
With relevant theories on time series clustering, the thesis makes research into similarity clustering process of time series from the perspective of singularity and proposes the time series clustering based on singularity applying K-means and DBScan ...
Ding, Xueli, Chang, Dan, Ma, Yunfang
core   +2 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Guided conjugate Bayesian clustering for uncovering rhythmically expressed genes [PDF]

, 2006
Background: An increasing number of microarray experiments produce time series of expression levels for many genes. Some recent clustering algorithms respect the time ordering of the data and are, importantly, extremely fast. The focus of this paper is
Millar, A. J., Smith, J. Q., Anderson, Paul E., Edwards, Kieron D.   +3 more
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source