Results 71 to 80 of about 18,151,738 (262)

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Efficient Time-Series Clustering through Sparse Gaussian Modeling

Algorithms
In this work, we consider the problem of shape-based time-series clustering with the widely used Dynamic Time Warping (DTW) distance. We present a novel two-stage framework based on Sparse Gaussian Modeling.
Dimitris Fotakis, Panagiotis Patsilinakos, Eleni Psaroudaki, Michalis Xefteris   +3 more
doaj   +1 more source

Time-series clustering for sensor fault detection in large-scale Cyber-Physical Systems [PDF]

Large-scale Cyber-Physical Systems (CPSs) are information systems that involve a vast network of sensor nodes and other devices that stream observations in real-time and typically are deployed in uncontrolled, broad geographical terrains.
Brimicombe, Allan, Falcarin, Paolo, Alwan, A., Ghorashi, Seyed, Baravalle, Andrea, Ciupala, Anca   +5 more
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Clustering life trajectories: A new divisive hierarchical clustering algorithm for discrete-valued discrete time series [PDF]

A new algorithm for clustering life course trajectories is presented and tested with large register data. Life courses are represented as sequences on a monthly timescale for the working-life with an age span from 16-65.
Dlugosz, Stephan
core  

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Exploring Optimal Strategies for Small Hydro Power Forecasting: Training Periods and Methodological Variations

Engineering Proceedings
This study investigates optimal training intervals for small hydro power regression models, crucial for accurate forecasts in diverse conditions, particularly focusing on Portugal’s small hydro portfolio.
Duarte Lopes, Isabel Preto, David Freire
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Unraveling Meteorological Dynamics: A Two-Level Clustering Algorithm for Time Series Pattern Recognition with Missing Data Handling

Stats
Identifying regions with similar meteorological features is of both socioeconomic and ecological importance. Towards that direction, useful information can be drawn from meteorological stations, and spread in a broader area.
Ekaterini Skamnia, Eleni S. Bekri, Polychronis Economou   +2 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source