Results 91 to 100 of about 655,816 (301)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Time representation in reinforcement learning models of the basal ganglia [PDF]

, 2013
Reinforcement learning (RL) models have been influential in understanding many aspects of basal ganglia function, from reward prediction to action selection.
Sebastian eDupraz, Samuel Joseph Gershman, Ahmed A. Moustafa, Santiago eQuiroga, Ludvig, Elliot Andrew, Oksdath Mansilla, Mariana, Fernández, Marisa Mariel, Moustafa, Ahmed A., Nieto Guil, Alvaro Fernando, Maria Eugenia Bernis, Emilio L. Malchiodi, Gershman, Samuel J., Sebastián Dupraz, Silvana B. Rosso, Rosso, Silvana Beatriz, Elliot A. Ludvig, Malchiodi, Emilio Luis, Santiago Quiroga, Dupraz, Sebastian, Enrique, Mariana eOksdath, Alvaro Nieto Guil, Samuel J. Gershman, Alvaro F. Nieto Guil, María E. Bernis, Quiroga, Santiago, Marisa M. Fernandez, Ludvig, Elliot A., Moustafa, Ahmed A. (R17078), Bernis, Maria Eugenia, Mariana Oksdath   +29 more
core   +1 more source

Time-Series Representation Learning in Topology Prediction for Passive Optical Network of Telecom Operators. [PDF]

Sensors (Basel), 2023
Zhao H, Fang Y, Zhao Y, Tian Z, Zhang W, Feng X, Yu L, Li W, Fan H, Mu T.   +9 more
europepmc   +1 more source

Universal Time-Series Representation Learning: A Survey

CoRR
Time-series data exists in every corner of real-world systems and services, ranging from satellites in the sky to wearable devices on human bodies. Learning representations by extracting and inferring valuable information from these time series is crucial for understanding the complex dynamics of particular phenomena and enabling informed decisions ...
Patara Trirat, Yooju Shin, Junhyeok Kang, Youngeun Nam, Jihye Na, Minyoung Bae, Joeun Kim, Byunghyun Kim, Jae-Gil Lee 0001   +8 more
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Nonparametric Specification Testing for Nonlinear Time Series with Nonstationarity [PDF]

This paper considers a nonparametric time series regression model with a nonstationary regressor. We construct a nonparametric test for testing whether the regression is of a known parametric form indexed by a vector of unknown parameters.
Zudi Lu, Jiti Gao, Maxwell King, Dag Tjøstheim   +3 more
core  

Representation learning for clinical time series prediction tasks in electronic health records

BMC Medical Informatics and Decision Making, 2019
Background Electronic health records (EHRs) provide possibilities to improve patient care and facilitate clinical research. However, there are many challenges faced by the applications of EHRs, such as temporality, high dimensionality, sparseness, noise,
Tong Ruan, Liqi Lei, Yangming Zhou, Jie Zhai, Le Zhang, Ping He, Ju Gao   +6 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Temporal Data Modeling and Reasoning for Information Systems [PDF]

, 2006
Temporal knowledge representation and reasoning is a major research field in Artificial Intelligence, in Database Systems, and in Web and Semantic Web research.
Spranger, Stephanie, Bry, François
core   +1 more source