Results 61 to 70 of about 655,816 (301)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
IEEE Access, 2021 Multivariate electricity consumption series clustering can reflect the trend of power consumption changes in the past time period, which can provide reliable guidance for electricity production.
Kaihong Zheng +5 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Robust Time Series Contrastive Representation Learning via Explicit Seasonal-Trend Disentanglement
IEEE AccessWe address universal self-supervised representation learning for time series under label scarcity and distribution shifts. A key challenge is that prevalent encode-then-decompose pipelines only implicitly separate seasonal and trend signals, which mixes ...
Fuyu Li, Bo Jin
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Dynamic Sub-Sequence Warping: A Representation-Based Similarity Measure for Long Time Series
Data Science and EngineeringDynamic time warping (DTW), a typical elastic similarity measure that compares one-to-many points, has been proven effective for various time-series data mining tasks. However, it requires a quadratic time complexity $$O(n^2)$$ proportional to the length
Zhou Zhou, Gang Huang, Laura Dawkins
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Outlier detection in multivariate time series via projection pursuit [PDF]
, 2004 This article uses Projection Pursuit methods to develop a procedure for detecting outliers in a multivariate time series. We show that testing for outliers in some projection directions could be more powerful than testing the multivariate series directly.
Peña, Daniel +2 more
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Nonlinear Error Correction Models [PDF]
, 2002 The relationship between cointegration and error correction (EC) models is well characterized in a linear context, but the extension to the nonlinear context is still a challenge.
Escribano, Álvaro, Mira, Santiago
core +1 more source