Results 51 to 60 of about 89,230,702 (250)

A Review on Joint Modelling of Longitudinal Measurements and Time-To-Even

Revstat Statistical Journal, 2011
In longitudinal studies subjects are measured for one or more response variable, over time. Although the underlying evolution of such response variables is continuous in time, in practice the measurements are observed at discrete time points.
Inês Sousa
doaj   +1 more source

From Qualitative to Quantitative AOP: A Case Study of Neurodegeneration

Frontiers in Toxicology, 2022
Adverse outcome pathways (AOPs) include a sequence of events that connect a molecular-level initiating event with an adverse outcome at the cellular level for human health endpoints, or at the population level for ecological endpoints.
Dennis Sinitsyn, Dennis Sinitsyn, Natàlia Garcia-Reyero, Karen H. Watanabe   +3 more
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Timing diagrams requirements modeling using Event-B formal methods [PDF]

, 2010
Timing diagrams provide an intuitive graphical specification for time constraints and causal dependencies between a system’s objects. Such a view can provide useful insight during Requirements Engineering (RE).
Snook, Colin, T. Joochim, M.R. Poppleton, C.F. Snook, Gravell, Andrew, Joochim, Tossaporn, Poppleton, Mike, A.M. Gravell   +7 more
core   +2 more sources

Multiplicative models for survival percentiles: estimating percentile ratios and multiplicative interaction in the metric of time

Epidemiology, Biostatistics and Public Health, 2016
Evaluating percentiles of survival was proposed as a possible method to analyze time-to-event outcomes. This approach sets the cumulative risk of the event of interest to a specific proportion and evaluates the time by which this proportion is attainedIn
Andrea Bellavia, Matteo Bottai, Nicola Orsini   +2 more
doaj   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

A regularized Cox hierarchical model for incorporating annotation information in predictive omic studies

BioData Mining
Background Associated with high-dimensional omics data there are often “meta-features” such as biological pathways and functional annotations, summary statistics from similar studies that can be informative for predicting an outcome of interest.
Dixin Shen, Juan Pablo Lewinger, Eric Kawaguchi   +2 more
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Clinical time-to-event prediction enhanced by incorporating compatible related outcomes

PLOS Digital Health, 2022
Accurate time-to-event (TTE) prediction of clinical outcomes from personal biomedical data is essential for precision medicine. It has become increasingly common that clinical datasets contain information for multiple related patient outcomes from ...
Yan Gao, Yan Cui
doaj  

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source