Results 101 to 110 of about 1,593,904 (291)

Cognitive-Behavioral Treatment for Depression in Adolescents [PDF]

open access: yes, 2005
The goal of this article is to briefly review and summarize the rationale and research support for cognitivebehavioral therapy (CBT) as a treatment for depressed adolescents.
Rohde, P
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

open access: yesMolecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Modelling treatment, age- and gender-specific recovery in acute injury studies [PDF]

open access: yes, 2010
Background: Acute injury studies often measure physical ability repeatedly over time through scores that have a finite range. This can result in a faster score change at the beginning of the study than towards the end, motivating the investigation of ...
Akacha, Mouna   +2 more
core  

Return to sports and physical activity after implantable shock absorber surgery for patients with medial knee osteoarthritis

open access: yesJournal of Cartilage & Joint Preservation
: Objectives: Symptomatic knee osteoarthritis (OA) is a leading cause of disability. High tibial osteotomy and knee arthroplasty can deliver excellent outcomes, but are complicated by morbidity, times, and activity limitation.
Seth L. Sherman   +3 more
doaj   +1 more source

Effects of kinesiology taping timing on recovery in the lower limbs

open access: yesFrontiers in Physiology
BackgroundKinesiology taping (KT) is widely used to support muscle function and recovery, but its optimal application timing remains unclear. While some suggest pre-exercise KT provides protective benefits, others propose post-exercise KT aids recovery.
Chia-Yu Tang   +8 more
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Pathogenesis of feline enteric coronavirus infection. [PDF]

open access: yes, 2008
Fifty-one specific pathogen-free (SPF) cats 10 weeks to 13 years of age were infected with a cat-to-cat fecal-oral passed strain of feline enteric coronavirus (FECV). Clinical signs ranged from unapparent to a mild and self-limiting diarrhea. Twenty-nine
Allen, Claire E   +2 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Are drug therapies effective in treating Bell's palsy? [PDF]

open access: yes, 2003
Early use of corticosteroid therapy results in less autonomic synkinesis and possibly improved rates of recovery in adults (strength of recommendation: C); there is no proven benefit in children (SOR: B).
Meadows, Susan E., Shannon, Scott E.
core  

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