Results 111 to 120 of about 3,745,051 (322)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Formation Consensus Control Method With Time-Varying Parameters Based on Virtual Leader

International Journal of Aerospace Engineering
A method of formation pattern alternation and consistent flight control in complex battlefield environment is put forward, considering the single formation pattern during formation flight and failing to deal with the changeable battlefield environment ...
Hongyun Wang, Xiwei Guo, Wenzhao Li, YaQin Li, Weiwei Gao   +4 more
doaj   +1 more source

Distributed Fixed-Time Nonsingular Terminal Sliding Mode Time-Varying Formation Control of ASVs Based on Hierarchical Control Mechanism

IEEE Access
This paper presents a distributed fixed-time nonsingular terminal sliding mode (FxTNTSM) time-varying formation control scheme based on a hierarchical control mechanism (HCM) for autonomous surface vessels (ASVs) with model parameter uncertainties and ...
Xiaolong Wang, Zhen Wang, Zunmin Li, Yanliang Bi   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Prescribed Performance Formation Tracking Control for Underactuated AUVs under Time-Varying Communication Delays

Journal of Marine Science and Engineering
Achieving formation tracking control of underactuated autonomous underwater vehicles (AUVs) under communication delays presents a significant challenge. To address this challenge, a distributed prescribed performance control protocol based on a real-time
Haitian Zhang, Yanqing Jiang, Rui Gao, Hang Li, Ao Li   +4 more
doaj   +1 more source

Estimating age-status-specific demographic rates that are consistent with the projected summary measures in family households projection [PDF]

This paper proposes procedures for estimating age-status-specific demographic rates to ensure that the projected summary measures of marriage/union formation and dissolution and marital and non-marital fertility in the future years are achieved ...
Eric Stallard, Yi Zeng, Zhenglian Wang
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source