Results 41 to 50 of about 459,982 (269)
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Dark-Energy Dynamics Required to Solve the Cosmic Coincidence
, 2008 Dynamic dark energy (DDE) models are often designed to solve the cosmic coincidence (why, just now, is the dark energy density $\rho_{de}$, the same order of magnitude as the matter density $\rho_m$?) by guaranteeing $\rho_{de} \sim \rho_m$ for ...
B. Carter +7 more
core +1 more source
Time-varying formation tracking of multiple manipulators via distributed finite-time control
Neurocomputing, 2016 Comparing with traditional fixed formation for a group of dynamical systems, time-varying formation can produce the following benefits: i) covering the greater part of complex environments; ii) collision avoidance. This paper studies the time-varying formation tracking for multiple manipulator systems (MMSs) under fixed and switching directed graphs ...
Ge, Ming-Feng +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
COORDINATION OF LEADER-FOLLOWER MULTI-AGENT SYSTEM WITH TIME-VARYING OBJECTIVE FUNCTION [PDF]
, 2017 This thesis aims to introduce a new framework for the distributed control of multi-agent systems with adjustable swarm control objectives. Our goal is twofold: 1) to provide an overview to how time-varying objectives in the control of autonomous systems ...
Fabian, Zalan Mark
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Safe, Remote-Access Swarm Robotics Research on the Robotarium [PDF]
, 2016 This paper describes the development of the Robotarium -- a remotely accessible, multi-robot research facility. The impetus behind the Robotarium is that multi-robot testbeds constitute an integral and essential part of the multi-agent research cycle ...
Ames, Aaron +7 more
core +1 more source
Analytic solutions and Singularity formation for the Peakon b--Family equations
, 2012 Using the Abstract Cauchy-Kowalewski Theorem we prove that the $b$-family equation admits, locally in time, a unique analytic solution. Moreover, if the initial data is real analytic and it belongs to $H^s$ with $s > 3/2$, and the momentum density $u_0 -
A. Degasperis +25 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source