Results 41 to 50 of about 808,169 (217)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
On the price and income elasticity of consumption in EU economies
Ekonomický ČasopisAlthough the marketing literature is abundant with studies dealing with the responsiveness of consumption to price changes, not much has been said about the elasticity of household expenditures from a macroeconomic perspective.
Petar Sorić
doaj +1 more source
Control system design of mechanical systems with time varying mechanical and control parameters
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2014 A new control framework of motion and/or vibration control system design for mechanical systems with a time varying mechanical and control parameters is studied. As examples of such time varying mechanical and control parameters, we can assume a variable
Kazuhiko HIRAMOTO
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A Concept of the Non-Stationary Filtering Network with Reduced Transient Response
Applied Sciences, 2019 This paper presents a concept of the non-stationary filtering network with reduced transient response consisting of the first-order digital elements with time-varying parameters. The digital filter section is based on the analog system.
Katarzyna Wiechetek, Jacek Piskorowski
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
How (i)rrational are we? A case of Croatian inflation
Croatian Operational Research Review, 2015 This paper examines the validity of the rational expectations hypothesis (REH) in the case of Croatian consumers and their inflation estimates. The added value of this paper in comparison to previous similar studies lies in the state space methodology ...
Nataša Erjavec +2 more
doaj +1 more source