Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Control system design of mechanical systems with time varying mechanical and control parameters
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2014 A new control framework of motion and/or vibration control system design for mechanical systems with a time varying mechanical and control parameters is studied. As examples of such time varying mechanical and control parameters, we can assume a variable
Kazuhiko HIRAMOTO
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Input-to-state stability for discrete-time time-varying systems with applications to robust stabilization of systems in power form [PDF]
, 2005 Input-to-state stability (ISS) of a parameterized family of discrete-time time-varying nonlinear systems is investigated. A converse Lyapunov theorem for such systems is developed.
Laila, D. S. +5 more
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Expected optimal feedback with Time-Varying Parameters [PDF]
In this paper we derive, by using dynamic programming, the closed loop form of the Expected Optimal Feedback rule with time varying parameter. As such this paper extends the work of Kendrick (1981, 2002, Chapter 6) for the time varying parameter case ...
Hans M. Amman +2 more
core
Robust H∞ control of time-varying systems with stochastic non-linearities: the finite-horizon case [PDF]
, 2010 The official published version can be obtained from the link below.This paper is concerned with the robust H∞ control problem for the class of uncertain non-linear discrete time-varying stochastic systems with a covariance constraint.
Wang, Z, Ma, L, Bo, Y, Guo, Z
core +1 more source
A sliding window approach to optimize the time-varying parameters of a spatially-explicit and stochastic model of COVID-19. [PDF]
PLOS Glob Public Health, 2022 Ratnavale S +3 more
europepmc +2 more sources