Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Prescribed-Time Leader-Follower Synchronization of Higher-Order Nonlinear Multi-Agent Systems via Fuzzy Neural Adaptive Sliding Control. [PDF]
Sensors (Basel)Ullah S +5 more
europepmc +1 more source
Time-varying lossless systems and the inversion of large structured matrices
, 1995 A. van Veen
openalex +1 more source
Robust Stabilization of Discrete‐Time Systems with Time‐Varying Delay: An LMI Approach [PDF]
, 2008 Valter J. S. Leite, Márcio F. Miranda
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Multidimensional strategy enables scalable metabolome diversity in microbial fermentations. [PDF]
Sci RepLindig A, Fataeri M, Hubmann G, Lütz S.
europepmc +1 more source
Stabilization of Time-Varying Perturbed Quantum Systems via Reduced Filters [PDF]
Weichao Liang, Daoyi Dong
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A Delay Decomposition Approach to the Stability Analysis of Singular Systems with Interval Time‐Varying Delay [PDF]
, 2014 Jianmin Jiao, Rui Zhang
openalex +1 more source
Research on Time-Varying Meshing Stiffness of Marine Bevoloid Gear System
, 2023 Jianmin Wen +3 more
openalex +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source