Results 91 to 100 of about 842,020 (274)

Generalized Analysis of Elastic Wave Dispersion Asymmetries in Moving Periodic Media

, 2018
This work presents a generalized physical interpretation of unconventional dispersion asymmetries associated moving elastic solids. By shifting the notion from systems with time-variant material fields to physically traveling materials, the newly adopted
Attarzadeh, M. A., Nouh, M.
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Nonlinear Passive Observer for Motion Estimation in Multi-Axis Precision Motion Control

Machines
A nonlinear passive observer (NPO) for estimating the time-varying velocity vector of a multi-axis high-precision motion control stage is presented. The proposed nonlinear estimation strategy is developed based on a Lyapunov stability analysis, which ...
Hector Gutierrez, Dengfeng Li
doaj   +1 more source

Wave-packet dynamics in slowly perturbed crystals: Gradient corrections and Berry-phase effects

, 1999
We present a unified theory for wave-packet dynamics of electrons in crystals subject to perturbations varying slowly in space and time. We derive the wave-packet energy up to the first order gradient correction and obtain all kinds of Berry-phase terms ...
B. Simon, D. J. Thouless, D. M. Bird, E. Brown, E. E. Mendes, E. H. Cohen, E. I. Blount, E. I. Blount, E. J. Heller, E. Kartheuser, E. N. Adams, E. N. Adams, F. S. Khan, G. H. Wannier, G. H. Wannier, G. H. Wannier, G. H. Wannier, G. Nenciu, G. Venkataraman, Ganesh Sundaram, H. Jones, H. Kuratsuji, J. B. Sokoloff, J. Bardeen, J. C. Slater, J. M. Luttinger, J. M. Luttinger, J. Zak, J. Zak, J. Zak, J. Zak, J. Zak, K. Kawamura, L. Kleinman, L. M. Roth, L. M. Roth, M. C. Chang, M. C. Chang, M. R. Geller, M. V. Berry, M. Wilkinson, M. Wilkinson, M. Wilkinson, N. W. Ashcroft, P. A. M. Dirac, P. G. Harper, Q. Niu, Q. Niu, Q. Niu, Qian Niu, R. Karplus, R. Peierls, R. Rammal, R. Resta, W. Kohn, W. Kohn, Y. Aharonov   +56 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Optimal Control-Based Algorithm Design and Application for Trajectory Tracking of a Mobile Robot with Four Independently Steered and Four Independently Actuated Wheels

Actuators
This paper deals with the synthesis and implementation of a controller for asymptotic tracking of the desired trajectory of a mobile robot. The mobile robot used for the experimental validation has eight motors with an inner control loop.
Branimir Ćaran, Vladimir Milić, Marko Švaco, Bojan Jerbić   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

High Repetition-Rate Wakefield Electron Source Generated by Few-millijoule, 30 femtosecond Laser Pulses on a Density Downramp

, 2012
We report on an experimental demonstration of laser wakefield electron acceleration using a sub-TW power laser by tightly focusing 30-fs laser pulses with only 8 mJ pulse energy on a 100 \mu m scale gas target.
A G R Thomas, Ammosov M V, Andreev N E, B Hou, Fonseca R A, J A Nees, J Faure, J H Easter, K Krushelnick, Trines R M G M, Whitham G B, Z-H He   +11 more
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source