Results 131 to 140 of about 53,156,886 (365)

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Modularity and Temporal Reasoning: a Logic Programming Approach [PDF]

, 2007
Albeit temporal reasoning and modularity are very prolific fields of research in Logic Programming (LP), we find few examples of their integration. In this paper we propose the addition of temporal annotations to a modular extension of LP.
Abreu, Salvador, Nogueira, Vitor
core   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Optimal Control for Simple Linear Hybrid Systems [PDF]

, 2016
This paper studies optimal time-bounded control in a simple subclass of linear hybrid systems, which consists of one continuous variable and global constraints. Each state has a continuous cost attached to it, which is linear in the sojourn time, while a
Mousa, Mahmoud AA, Schewe, Sven, Wojtczak, Dominik   +2 more
core   +1 more source

Research on Universal Time/Length of Day Combination Algorithm Based on Effective Angular Momentum Dataset

Remote Sensing
Given that effective angular momentum (EAM) data demonstrate a strong correlation with length of day (LOD) data and are extensively utilized in the prediction of the universal time (UT1), this research integrated the EAM into the design of a Kalman ...
Xishun Li, Yuanwei Wu, Dang Yao, Jia Liu, Kai Nan, Zewen Zhang, Weilong Wang, Xuchong Duan, Langming Ma, Haiyan Yang, Haihua Qiao, Xuhai Yang, Xiaohui Li, Shougang Zhang   +13 more
doaj   +1 more source

Chip-scale atomic diffractive optical elements

Nature Communications, 2019
Quantum coherence and the nonlinear properties of atoms are highly useful in optical devices. Here the authors show quantum-optic hybrid platforms in fully integrated chip-scale atomic diffractive optical elements by embedding hot atomic Rb vapor in ...
Liron Stern, Douglas G. Bopp, Susan A. Schima, Vincent N. Maurice, John E. Kitching   +4 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Compact Real-Time Inter-Frame Histogram Builder for 15-Bits High-Speed ToF-Imagers Based on Single-Photon Detection [PDF]

, 2019
Time-of-flight (ToF) image sensors based on single-photon detection, i.e., SPADs, require some filtering of pixel readings. Accurate depth measurements are only possible if the jitter of the detector is mitigated.
Carmona Galán, Ricardo, Darie, Ángela, Rodríguez Vázquez, Ángel Benito, Vornicu, Ion   +3 more
core   +1 more source

Estimating Transit Vehicle Dwell Times at Bus Stops [PDF]

arXiv, 2020
This work presents a quantitative approach to estimate the total time spent in the vicinity of a bus stop including the deceleration time, the boarding and alighting time (developed in an earlier study), the acceleration time, and re-entry time (time required to merge into the adjacent lane).
arxiv  

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source