Results 1 to 10 of about 731,597 (291)
Modeling the Arrows of Time with Causal Multibaker Maps
EntropyWhy do we remember the past, and plan the future? We introduce a toy model in which to investigate emergent time asymmetries: the causal multibaker maps. These are reversible discrete-time dynamical systems with configurable causal interactions. Imposing
Aram Ebtekar, Marcus Hutter
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
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A new species and two newly-recorded species of the genus Micrencaustes (Coleoptera, Erotylidae) from China [PDF]
Biodiversity Data JournalThe genus Micrencaustes Crotch, 1876 (Coleoptera, Cucujoidea, Erotylidae, Erotylinae, Encaustini) includes 44 known species worldwide, 11 species having been reported to occur in China.
Yuhang Yang +3 more
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Astronomy and Geophysics, 1971 If we are unfortunate enough to drop a basket of eggs we may rightly feel dismayed. For even with the most painstaking human manipulation it is surely not possible to reassemble the broken pieces.
openaire +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The Arrow of Time: Challenges for Sociological Knowledge
Социологическая наука и социальная практика, 2014 The author analyzes new challenges appeared as a result of the becoming of the complex socium. It is shown that these vulnerabilities manifest new risks for the functioning of the society and its members.
Sergey A. Kravchenko
doaj
Gravitational Entropy and Inflation
Entropy, 2013 The main topic of this paper is a description of the generation of entropy at the end of the inflationary era. As a generalization of the present standard model of the Universe dominated by pressureless dust and a Lorentz invariant vacuum energy (LIVE ...
Øystein Elgarøy, Øyvind Grøn
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