Results 121 to 130 of about 12,731,770 (288)

The black arrow : a tale of the two roses /

, 1888
In fifteenth-century England, when his father's murderer is revealed to be his guardian, seventeen-year-old Richard Shelton joins the fellowship of the Black Arrow in avenging the death, rescuing the woman he loves, and participating in the struggle ...
Stevenson, Robert Louis, 1850-1894
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Arrow Lakes Historical Society Books & Manuscripts

, 1965
This collection contains digital copies of publications from the holdings of the Arrow Lakes Historical Society Archives with the necessary copyright ...

core  

Time-lapse quantitative phase images of RPE-1 cells in 50 nM palbociclib; the time interval is 30 min; the yellow arrow indicates the lost cytoplasmic mass of a mitotic cell (red arrow); the scale bar indicates 100 μm.

Time-lapse quantitative phase images of RPE-1 cells in 50 nM palbociclib; the time interval is 30 min; the yellow arrow indicates the lost cytoplasmic mass of a mitotic cell (red arrow); the scale bar indicates 100 μm.
Jiawei Yan (1630237), Marc W. Kirschner (230836), Xili Liu (313812)   +2 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Emergence of opposing arrows of time in open quantum systems

Scientific Reports
Deriving an arrow of time from time-reversal symmetric microscopic dynamics is a fundamental open problem in many areas of physics, ranging from cosmology, to particle physics, to thermodynamics and statistical mechanics.
Thomas Guff, Chintalpati Umashankar Shastry, Andrea Rocco   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Time-reversal invariance and irreversibility in time-asymmetric quantum mechanics [PDF]

, 2005
The aim of this paper is to analyze the concepts of time-reversal invariance and irreversibility in the so-called 'time-asymmetric quantum mechanics'. We begin with pointing out the difference between these two concepts.
Castagnino, Mario, Gadella, Manuel, Lombardi, Olimpia, Mario Castagnino, Olimpia Lombardi, Manuel Gadella   +5 more
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source