Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
A Real-Time Comparison of Four Particulate Matter Size Fractions in the Personal Breathing Zone of Paris Subway Workers: A Six-Week Prospective Study. [PDF]
Sustainability, 2022 Pétremand R +4 more
europepmc +1 more source
A comparison of time-domain time-scale modification algorithms
, 2006 Time-domain approaches to time-scale modification are popular due to their ability to produce high quality results at a relatively low computational cost. Within the category of time-domain implementations quite a number of alternatives exist, each with their own computational requirements and associated output quality.
Dorran, David +2 more
openaire +3 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Prediction of retention time in larger antisense oligonucleotide datasets using machine learning
Machine Learning with ApplicationsAntisense oligonucleotides (ASOs) are nucleic acid molecules with transformative therapeutic potential, especially for diseases that are untreatable by traditional drugs.
Manal Rahal +4 more
doaj +1 more source
[Time comparison of artificial airway establishment in operating room and on slope using endotracheal intubation and laryngeal mask]. [PDF]
Beijing Da Xue Xue Bao Yi Xue Ban, 2022 Bai P +5 more
europepmc +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Long term behavior of solutions for Riccati initial-value problems
Electronic Journal of Differential Equations, 2008 The Riccati equation has been known since the early 1700s. Numerous papers have been written on the solvability of its special cases. However, to the best of our knowledge, there are no papers that investigate the exact (equation specific) conditions
Stefan C. Johnson +2 more
doaj
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Applied SciencesOver the past two decades, Olympic swimming performance has improved. However, less attention has been given to the evolution of Olympic Qualification Time (OQT) standards.
Iván Petrov +5 more
doaj +1 more source