Results 41 to 50 of about 15,433,823 (259)
Frontiers in Systems Neuroscience, 2015 The discovery of time cells revealed that the rodent hippocampus has information of time.Previous studies have suggested that a role of hippocampal time cells is to integratetemporally segregated events into a sequence using working memory with time ...
Tomoaki eNakazono +5 more
doaj +1 more source
eLife, 2021 Spatial hearing in cochlear implant (CI) patients remains a major challenge, with many early deaf users reported to have no measurable sensitivity to interaural time differences (ITDs).
Nicole Rosskothen-Kuhl +3 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Stream-based Hebbian eigenfilter for real-time neuronal spike discrimination
BioMedical Engineering OnLine, 2012 Background Principal component analysis (PCA) has been widely employed for automatic neuronal spike sorting. Calculating principal components (PCs) is computationally expensive, and requires complex numerical operations and large memory resources ...
Yu Bo +5 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The effect of stimulus range on two-interval frequency discrimination [PDF]
, 2008 It has traditionally been thought that performance in two-interval frequency discrimination tasks decreases as the range over which the standard tone varies is increased. Recent empirical evidence and a reexamination of previous results suggest that this
Matthews, William J. +4 more
core +1 more source
Real-time gamma-neutron discrimination with a trainable polynomial kernel [PDF]
EPJ Web of ConferencesThis paper presents an implementation of gamma-neutron pulse shape discrimination by a support vector machine polynomial decision function in a field-programmable gate array.
Hlavinka Matyáš +4 more
doaj +1 more source