Results 101 to 110 of about 6,163,357 (346)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Time-domain Ramsey interferometry with interacting Rydberg atoms

, 2016
We theoretically investigate the dynamics of a gas of strongly interacting Rydberg atoms subject to a time-domain Ramsey interferometry protocol. The many-body dynamics is governed by an Ising-type Hamiltonian with long range interactions of tunable ...
Genes, Claudiu, Ohmori, Kenji, Pupillo, Guido, Sommer, Christian, Takeda, Shuntaro, Takei, Nobuyuki, Tanaka, Akira   +6 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

TasNet: time-domain audio separation network for real-time, single-channel speech separation

, 2018
Robust speech processing in multi-talker environments requires effective speech separation. Recent deep learning systems have made significant progress toward solving this problem, yet it remains challenging particularly in real-time, short latency ...
Luo, Yi, Mesgarani, Nima
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Time-domain simulation of the full hydrodynamic model

, 2003
A simple upwind discretization of the highly coupled non-linear differential equations which define the hydrodynamic model for semiconductors is given in full detail.
Alsunaidi, Baccarani, Blotekjaer, Caughey, Feng, Gardner, Gnudi, Scharfetter, Tang, Tomizawa   +9 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Stacked ensemble machine learning approach for electroencephalography based major depressive disorder classification using temporal statistics

Systems Science & Control Engineering
Major depressive disorder (MDD) is a serious and widespread mental health condition that remains challenging to diagnose accurately. Traditional psychological assessments, which can be subjective and sometimes unreliable, emphasize the need for more ...
Nader Nisar Ahmed, Tejas Kadengodlu Bhat, Omkar S. Powar   +2 more
doaj   +1 more source

Method for identifying ageing in epoxy-mica composite insulation used in rotational machines through modelling of dielectric relaxation

High Voltage, 2019
Dielectric response analysis, performed in time domain and frequency domain is one of the interesting methods used for condition assessment of high voltage equipment.
Nikhil Mondal, Nasirul Haque, Sovan Dalai, Sivaji Chakravorti, Biswendu Chatterjee   +4 more
doaj   +1 more source