Results 221 to 230 of about 6,163,357 (346)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Time-Domain Visualization of Electron-Phonon Coupling in Nanographenes. [PDF]

Small Methods
Muñoz-Mármol R, Raj S, Russo M, Serra G, Zhao H, Bassi G, Lucotti A, Scotognella F, Cerullo G, Lanzani G, Tommasini M, Maiuri M, Narita A, Paternò GM.   +13 more
europepmc   +1 more source

Using Non-stationary Time-Domain Statistical Measures for Predictive Maintenance of Large Centrifugal Compressors in the Absence of Component Faults

Kihong Shin
openalex   +1 more source

Time‐Domain and Morphological Analysis of the P‐Wave. Part I: Technical Aspects for Automatic Quantification of P‐Wave Features [PDF]

, 2008
Federica Censi, Chiara Ricci, Giovanni Calcagnini, Michele Triventi, Renato Pietro Ricci, Massimo Santini, P. Bartolini   +6 more
openalex   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Approaches for modelling autocorrelation function and data processing in time-domain diffuse correlation spectroscopy. [PDF]

Biomed Opt Express
Sudakou A, Tachtsidis I, Kacprzak M, Liebert A, Wojtkiewicz S.   +4 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Bioelectrical Impedance-Based Time-Domain Analysis for Cerebral Autoregulation Assessment. [PDF]

Sensors (Basel)
Zhou Y, He W, Yang B, Shi X, Liu Y, Shi Y, Fu F.   +6 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Fluorescence Lifetime Imaging Application to Probe GTPase Activation in Macrophage Cell Line, Using the Time-Domain FastFLIM Modality. [PDF]

Methods Mol Biol
Miskolci V, de Assis Lima M, Cox D, Hodgson L.   +3 more
europepmc   +1 more source